Artículo
Association of the dopamine D2 receptor rs1800497 polymorphism with food addiction, food reinforcement, and eating behavior in Chilean adults
Fecha
2022-02Autor
Universidad San Sebastián
Universidad San Sebastián
Universidad San Sebastián
Universidad San Sebastián
Universidad San Sebastián
Universidad San Sebastián
Universidad San Sebastián
Obregón, Ana M.
Oyarce, Karina
García-Robles, María A.
Valladares, Macarena
Pettinelli, Paulina
Goldfield, Gary S.
Institución
Resumen
Purpose: The regulation of food intake and body weight involves two interacting systems: (a) The homeostatic system (including biological regulators of hunger and satiety) and (b) the non-homeostatic system, (involving concepts of food reinforcement and food addiction). Studies have established a strong genetic component in eating behavior and obesity. The TaqI A1 polymorphism (rs1800497) has previously been associated with eating behavior, diminished dopamine D2 receptor (DRD2) density, higher body mass, and food reinforcement, but relations to food addiction remain unclear. Aim: To evaluate the association between the polymorphism rs1800497 with eating behavior, food reinforcement and food addiction in Chilean adults. Methods: This cross-sectional study recruited a convenience sample of 97 obese, 25 overweight and 99 normal-weight adults (18–35 years). Anthropometric measurements were performed by standard procedures. Eating behavior was assessed using the: Yale Food Addiction Scale (YFAS), the Three Factor Eating Behavior Questionnaire and the Food Reinforcement Value Questionnaire (FRVQ). The DRD2 genotype (rs1800497) was determined by taqman assays. Results: Twenty-two percentage of the participants met the criteria for food addiction. Food addiction was higher in women than men (26% vs 10.7%) and in obese compared to non-obese (40% vs 6%). There was no relationship between food addiction and DRD2 genotype. However when stratified by sex and nutritional status, obese female carriers of the A1 allele reported greater scores on emotional eating and snack food reinforcement compared to non-carriers. Conclusions: The DRD2 polymorphism is associated with some hedonic aspects of eating behavior, namely food reinforcement and emotional eating but not food addiction, and this association may be moderated by sex and obesity status, with obese women who are carriers of this genetic variant at higher risk. Level of evidence: Level V: evidence obtained from a cross-sectional descriptive study.
Materias
Ítems relacionados
Mostrando ítems relacionados por Título, autor o materia.
-
Guía infográfica de las aves del campus de la Pontificia Universidad Javeriana : Sede central
Echeverry-Galvis, Maria Angela; Cortés Cano, Juan Sebastián; Juan Sebastián, Sergio Andrés; Zapata Montoya, Sebastián; Botiva, Daniel Yesid; Linero, Daniela; Orozco, Daniela; Medina, Juan Sebastián; Sánchez, Juan Sebastián; Zuluaga, Juliana; Gómez, Laura María; Erazo, Paula Andrea; Ortegón, Salomé; Niño, Stephanie; Bocanegra, Valentina; Cardona, Valentina; Rincón, Víctor Julio; Moreno, Johan Sebastian; Jiménez, ValeriaEn las áreas urbanas las aves les dan a los ciudadanos un contacto directo con la vida silvestre. Su presencia es esencial para la polinización de jardines y huertas urbanas, para el control de poblaciones de roedores y ... -
Guía infográfica de las aves del campus de la Pontificia Universidad Javeriana : Sede central
Echeverry-Galvis, Maria Angela; Cortés Cano, Juan Sebastián; Juan Sebastián, Sergio Andrés; Zapata Montoya, Sebastián; Botiva, Daniel Yesid; Linero, Daniela; Orozco, Daniela; Medina, Juan Sebastián; Sánchez, Juan Sebastián; Zuluaga, Juliana; Gómez, Laura María; Erazo, Paula Andrea; Ortegón, Salomé; Niño, Stephanie; Bocanegra, Valentina; Cardona, Valentina; Rincón, Víctor Julio; Moreno, Johan Sebastian; Jiménez, ValeriaEn las áreas urbanas las aves les dan a los ciudadanos un contacto directo con la vida silvestre. Su presencia es esencial para la polinización de jardines y huertas urbanas, para el control de poblaciones de roedores y ... -
Niveles de empatía en estudiantes de Odontología de la Universidad San Sebastián, Concepción, Chile
Universidad San Sebastián; Universidad San Sebastián; Universidad San Sebastián; Torres-Martínez, Pilar Alejandra; Barrios-Penna, Carolina Alejandra; Fonseca-Molina, Juan Fernando; Díaz-Narváez, Víctor Patricio; González-Cruz, Sebastián Alejandro (2017)Introduction: The training of future dentists should consider developing empathy while they are still students. The first step to consider such training is to assess empathic behavior. Objective: To measure levels of empathy ...