Universidad San Sebastián (Chile): últimos ingresos
Mostrando ítems 441-460 de 2845
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Mechanotransduction and epigenetic control in autoimmune diseases
(2011-01)Differentiation of epithelial cells is required to define tissue architecture and appropriate function of these cells is associated with a specific pattern of gene expression. DNA methylation, post-translational modification ... -
Sjögren's syndrome and the epithelial target : A comprehensive review
(2013-05)The most difficult component in our understanding of human autoimmunity remains a rigorous dissection of etiological events. Indeed, the vast literature on autoimmune diseases focuses on the inflammatory response, with the ... -
Impaired IRE1α/XBP-1 pathway associated to DNA methylation might contribute to salivary gland dysfunction in Sjögren's syndrome patients
(2018-06-01)Objectives. Labial salivary glands (LSGs) of SS patients show alterations related to endoplasmic reticulum stress. Glandular dysfunction could be partly the consequence of an altered inositol-requiring enzyme 1α (IRE1α)/X ... -
Gene expression and chromosomal location for susceptibility to Sjögren's syndrome
(2009-09)Primary Sjögren's syndrome (SS) is a chronic inflammatory autoimmune disease affecting mainly the exocrine glands. Its physio-pathology is poorly understood and most of the knowledge has been related to the inflammatory ... -
Differential expression of matrix metalloproteinases in labial salivary glands of patients with primary Sjogren's syndrome : Mechanisms of exocrine parenchyma destruction
(2000)Objective. To determine the enzymatic activity and cellular localization of matrix metalloproteinases (MMPs) 2, 3, and 9 in labial salivary glands from patients with different degrees of severity of primary Sjogren's ... -
Decreased salivary sulphotransferase activity correlated with inflammation and autoimmunity parameters in Sjögren's syndrome patients
(2012-03)Objectives: To determine the expression and enzymatic activities of sulphotransferases involved in mucin hyposulphation in labial salivary glands (LSGs) from SS patients and to correlate sulphotransferase activity with ... -
Pro-inflammatory cytokines enhance ERAD and ATF6α pathway activity in salivary glands of Sjögren's syndrome patients
(2016-12-01)Salivary gland (SG) acinar-cells are susceptible to endoplasmic reticulum (ER) stress related to their secretory activity and the complexity of synthesized secretory products. SGs of Sjögren's syndrome patients (SS)-patients ... -
Reduced sulfation of MUC5B is linked to xerostomia in patients with Sjögren syndrome
(2008-10)Objectives: MUC5B contains sulfated and sialylated oligosaccharides that sequester water required for moisturising the oral mucosa. Xerostomia, in patients with Sjögren syndrome, is generally associated with reduced ... -
Connexinopathies : A structural and functional glimpse
(2016-05-24)Mutations in human connexin (Cx) genes have been related to diseases, which we termed connexinopathies. Such hereditary disorders include nonsyndromic or syndromic deafness (Cx26, Cx30), Charcot Marie Tooth disease (Cx32), ... -
Habituation of Auditory Steady State Responses Evoked by Amplitude-Modulated Acoustic Signals in Rats.
(2015-01-21)Generation of the auditory steady state responses (ASSR) is commonly explained by the linear combination of random background noise activity and the stationary response. Based on this model, the decrease of amplitude that ... -
Multiple dose toxicity study of the humanized anti-epidermal growth factor receptor monoclonal antibody h-R3 intravenously administered to Cercopithecus aethiops sabaeus monkeys.
(2004-05-01)The h-R3 is a humanized growth factor receptor monoclonal antibody (mAb) in development for the treatment of head and neck tumours in which malignant cells overexpress the Epidermal Growth Factor receptor. The present study ... -
Cellular mechanisms linking to outdoor and indoor air pollution damage during pregnancy
(2023)Pregnancies are a critical window period for environmental influences over the mother and the offspring. There is a growing body of evidence associating indoor and outdoor air pollution exposure to adverse pregnancy outcomes ... -
PLACERES DEL PODER EN VALPORNO DE NATALIA BERBELAGUA
(2022-12-01)In this article, we analyze the function and representation of eroticism in Natalia Berbelagua’s Valporno. We propose to interpret the collection of stories from two concepts to understand the scope of the erotic phenomenon ...