Article
DNA and Oxidative Damages Decrease After Ingestion of Folic Acid in Patients with Type 2 Diabetes
Fecha
2003Autor
Franco-Gordo, C.
Godinez-Dominguez, E.
Suarez-Morales, E.
Vasquez-Yeomans, L.
Institución
Resumen
The seasonal variation in the diversity of ichthyoplankton was analyzed from samples collected monthly during a year cycle off the central Pacific coast of Mexico. Samples were collected using a Bongo net at 12 stations during 11 months, from December 1995 through December 1996. The most dominant species was Bregmaceros bathymaster, its relative density varied between 77 and 98%. Two main seasonal patterns were revealed after analyzing the dynamics of the coastal water mass and the ichthyoplankton assemblage ordination in relation to diversity. Diversity values (jack-knifed H = 0.24) were relatively low from January to May, and indicated a first seasonal pattern, related to a period dominated by the influence of the California Current, with surface temperatures ranging between 21 and 24°C. The second pattern was featured by diversity values five-fold higher than in the winter-spring (H = 0.92). These were related to the influence of warm, tropical waters from the Equatorial Countercurrent, with associated temperatures ranging between 26 and 29.2°C. A transitional period was identified in June and December; it represented a mixed assemblage and yielded the highest richness. Diversity null models were useful as tools to confirm the major seasonal patterns of the surveyed ichthyoplankton community. " 2003 Elsevier Science B.V. All rights reserved.",,,,,,"10.1016/S0272-7714(02)00335-9",,,"http://hdl.handle.net/20.500.12104/40764","http://www.scopus.com/inward/record.url?eid=2-s2.0-0042709458&partnerID=40&md5=994ede447e1b1353958d2534fa9c1b05",,,,,,"01-feb",,"Estuarine, Coastal and Shelf Science",,"111 121",,"57",,"Scopus WOS",,,,,,"Continental shelf; Diversity; Fish larvae; Null models; Probability of interspecific encounter; Rarefaction; Shannon index",,,,,,"Diversity of ichthyoplankton in the central Mexican Pacific: A seasonal survey",,"Article"
"42550","123456789/35008",,"Lazalde-Ramos, B.P., Unidad Académica de Medicina Humana, Universidad Autónoma de Zacatecas, Zacatecas, Mexico; Zamora-Perez, A.L., Instituto de Investigación en Odontología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; Sosa-Macías, M., Laboratorio de Farmacogenética y Biomedicina Molecular, CIIDIR-IPN Unidad Durango, Durango, Mexico; Guerrero-Velázquez, C., Instituto de Investigación en Odontología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; Zúñiga-González, G.M., Laboratorio de Mutagénesis, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, Mexico",,"Lazalde-Ramos, B.P. Zamora-Perez, A.L. Sosa-Macias, M. Guerrero-Velazquez, C. Zuniga-Gonzalez, G.M.",,"2012",,"Background and Aims: Type 2 diabetes mellitus (T2DM) is a chronic degenerative disease that promotes autoxidation of sugars, leading to the production of reactive oxygen species. This damage occurs especially at the level of cellular proteins, carbohydrates, lipids and DNA, thus playing an important role in the pathogenesis of late complications of T2DM. We investigated the effect of folic acid on DNA and oxidative damage in patients with T2DM. Methods: We studied 30 individuals diagnosed with T2DM and 30 control individuals without disease. Individuals with T2DM were prescribed 5 mg of folic acid, taken orally three times daily for 1 month. Samples were taken 15 and 30 days after treatment. DNA damage was determined using the micronucleus test in oral mucosa and oxidative stress by quantifying 8-hydroxy-2'-deoxyguanosine (8-OHdG) as well as by quantifying total lipid peroxides. Results: Individuals with T2DM had a higher number of micronuclei as well as higher levels of 8-OHdG and lipid peroxides than the control group (p = 0.001). Individuals with T2DM showed a significant reduction in the number of micronuclei and the concentration of 8-OHdG and lipid peroxides over time with folic acid intake. Conclusions: A positive correlation exists between oxidative stress produced by T2DM and DNA damage, so the use of an antioxidant such as folic acid in DM2 therapy is advisable for delaying complications due to T2DM-induced oxidative stress and DNA damage. " 2012 IMSS.