Nitazoxanide in the treatment of Ascaris lumbricoides in a rural zone of Colima, Mexico

Abstract

Functionalized carbene ligands: Increasing the steric bulk of R1 on 1 from H to tBu results in lengthening of the M-N bond (by up to 9 %), lowered activation energy for chelate opening (cf. 2) by 17 kcal mol -1, and improved binding of an amine and intramolecular hydrogen bonding (3). Iridium species with R1=tBu are effective catalysts of base-free intramolecular hydroamination, unlike less-hindered analogues. Copyright " 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.",,,,,,"10.1002/chem.201100521",,,"http://hdl.handle.net/20.500.12104/41220","http://www.scopus.com/inward/record.url?eid=2-s2.0-79957957253&partnerID=40&md5=e5f420da903f48ac5c6ea8173f95b40d",,,,,,"24",,"Chemistry - A European Journal",,"6606

6609",,"17",,"Scopus",,,,,,"cyclization; iridium; N-heterocyclic carbenes; NMR spectroscopy; pendant base",,,,,,"Enabling bifunctionality and hemilability of N-heteroaryl NHC complexes",,"Article" "44925","123456789/35008",,"Galvan-Ramirez, M.L., Laboratorio de Fisiología, Centro Universitario en Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; Rivera, N., Laboratorio de Fisiología, Centro Universitario en Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; Loeza, M.E., Laboratorio de Fisiología, Centro Universitario en Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; Avila, X., Laboratorio de Fisiología, Centro Universitario en Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; Acero, J., Laboratorio de Fisiología, Centro Universitario en Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; Troyo, R., Laboratorio de Fisiología, Centro Universitario en Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; Bernal, R., Laboratorio de Parasitología Y Micología, Hospital Infantil de Mexico Federico Gómez, México, D.F., Mexico",,"Galvan-Ramirez, M.L.

Rivera, N.

Loeza, M.E.

Avila, X.

Acero, J.

Troyo, R.

Bernal, R.",,"2007",,"Intestinal parasites in Mexico are an endemic problem. A study was conducted in children, teenagers and adults in a rural community in Colima, Mexico to examine the prevalence and intensity of Ascaris lumbricoides infection and to evaluate the parasitological and clinical efficacy of nitazoxanide (NTZ). Two hundred and eighty children, teenagers and adults participated in this study. Parasitological diagnosis from faeces was confirmed by three consecutive stool samples using the floatation concentration Faust method. Egg counts were performed as described by the Kato-Katz technique before and after treatment. A questionnaire was systematically applied to obtain information about socio-economic status and hygienic habits. One hundred and six participants (38%) were diagnosed as harbouring intestinal parasites, and 86 of them (81%) were infected with A. lumbricoides. All patients with ascariasis infections underwent a complete physical examination before and after NTZ treatment. NTZ resolved 88% of the ascariasis cases, with a 89% clinical efficacy, and there was a 97.5% reduction in the levels of morbidity. The most intense infections for A. lumbricoides were found in housewives, and statistically significant associations were found between ascariasis and the absence of drainage and living in houses with dirt floors. " 2007 Cambridge University Press.