Multicentre study of liver metastases from colorectal cancer in pathological livers.

Abstract

Insertion-deletions for human identification purposes (HID-Indels) offer advantages to solve particular forensic situations and complex paternity cases. In Mexico, admixed population known as Mestizos is the largest (~90%), plus a number of Amerindian groups (~10%), which have not been studied with HID-Indels. For this reason, allele frequencies and forensic parameters for 38 HID-Indels were estimated in 531 unrelated individuals from one Amerindian (Purepecha) and seven Mestizo populations from different regions of the country. Genotype distribution was in agreement with Hardy-Weinberg expectations in almost all loci/populations. The linkage disequilibrium (LD) test did not reveal possible associations between loci pairs in all eight Mexican populations. The combined power of discrimination was high in all populations (PD >99.99999999998%). However, the power of exclusion of the 38 HID-Indel system (PE >99.6863%) was reduced regarding most of autosomal STR kits. The assessment of genetic structure (AMOVA) and relationships between populations (FST) demonstrated significant differences among Mexican populations, mainly of the Purepecha Amerindian group. Among Mexican-Mestizos, three population clusters consistent with geography were defined: (i) North-West region: Chihuahua, Sinaloa, and Jalisco; (ii) Central-Southern region: Mexico City, Veracruz and Yucatan; (iii) South region: Chiapas. In brief, this report validates the inclusion of the 38 HID-Indel system in forensic casework and paternity cases in seven Mexican-Mestizo populations from different regions, and in one Mexican Amerindian group. Copyright ?" 2015 Elsevier Ireland Ltd. All rights reserved.",,"Record Owner: From MEDLINE, a database of the U.S. National Library of Medicine.; Status: In-Data-Review; Publishing Model: Journal available in: Print-Electronic Citation processed from: Internet; NLM Journal Code: 101317016; Keyword Heading: Amerindians Insertion-deletion polymorphisms Mestizos Mexico Paternity cases Purepechas; Publisher Item Identifier: S1872-4973(15)30003-X",,,,"10.1016/j.fsigen.2015.04.011",,"1878-0326; 1872-4973","http://hdl.handle.net/20.500.12104/37383","http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=25988907",,"English",,,,,,"Forensic science international",,"149

152",,"17",,"MEDLINE",,,,,,,,,,,,"Genetic structure and forensic parameters of 38 Indels for human identification purposes in eight Mexican populations.",,"Journal Article" "39169","123456789/35008",,"Wiener,A S. Serological Laboratory of the Office of the Chief Medical Examiner of the City of New York, and the University of Guadalajara, Mexico.",,"Wiener AS

Zepeda JP

Sonn EB

Polivka HR",,"1945",,"98 Mexican Indians were tested for the blood properties A-B-O, A(1)-A(2), M-N, P, Rh'-Rh''-Rh(0)-rh, and Hr. Of the 98 Indians, 90.8 per cent belonged to group 0, 6.1 per cent belonged to A(1), and 3.1 per cent to group B. There were 61.2 per cent of type M, 3.1 per cent of type N, and 35.7 per cent of type MN. Of the 95 Mexican Indians tested with anti-P serum, 21.1 per cent were found to lack the P agglutinogen. In tests for the Rh blood types, 48.0 per cent of the Indians were found to belong to type Rh(1), 9.2 per cent to type Rh(2), 41.8 per cent to type Rh(1)Rh(2), and 1 per cent to type Rh(0). There were no bloods giving intermediate reactions. Of the 95 Indians tested for the Hr factor 44.2 per cent were found to lack this property. The reactions for the Rh blood types and Hr factor were correlated with each other and the results supported the conclusion of Race et al. that in addition to the six standard allelic genes and the so called intermediate genes, there is one or possibly two genes having the property of determining agglutinogens which react with anti-Rh' and anti-Rh'' sera, but not with anti-Hr serum. This gene (or genes) appears to be relatively common among Mexican Indians (approximately 3.3 per cent) in contrast to its rareness in white individuals.",,"Record Owner: From MEDLINE, a database of the U.S. National Library of Medicine.; Status: PubMed-not-MEDLINE; Publishing Model: Journal available in: Print Citation processed from: Print; NLM Journal Code: i2v, 2985109r; Entry Date: 20100623",,,,,,"0022-1007; 0022-1007","http://hdl.handle.net/20.500.12104/37390","http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=19871476",,"English",,,,"6",,"Journal of Experimental Medicine",,"559

571",,"81",,"MEDLINE",,,,,,,,,,,,"INDIVIDUAL BLOOD DIFFERENCES IN MEXICAN INDIANS, WITH SPECIAL REFERENCE TO THE Rh BLOOD TYPES AND Hr FACTOR.",,"Journal Article" "39170","123456789/35008",,"Tirabassi,Giulio. Departament de Fisica i Enginyeria Nuclear, Universitat Politecnica de Catalunya, 08222 Terrassa, Barcelona, Spain. Sevilla-Escoboza,Ricardo. Center for Biomedical Technology, Technical University of Madrid, Pozuelo de Alarcon, 28223 Madrid, Spain. Buldu,Javier M. 1] Centro Universitario de los Lagos, Universidad de Guadalajara, Lagos de Moreno, Jalisco 47460, Mexico [2] Complex Systems Group, Universidad Rey Juan Carlos, 28933 Mostoles, Madrid, Spain. Masoller,Cristina. Departament de Fisica i Enginyeria Nuclear, Universitat Politecnica de Catalunya, 08222 Terrassa, Barcelona, Spain.",,"Tirabassi G

Sevilla-Escoboza R

Buldu JM

Masoller C",,"2015",,"A system composed by interacting dynamical elements can be represented by a network, where the nodes represent the elements that constitute the system, and the links account for their interactions, which arise due to a variety of mechanisms, and which are often unknown. A popular method for inferring the system connectivity (i.e., the set of links among pairs of nodes) is by performing a statistical similarity analysis of the time-series collected from the dynamics of the nodes. Here, by considering two systems of coupled oscillators (Kuramoto phase oscillators and Rossler chaotic electronic oscillators) with known and controllable coupling conditions, we aim at testing the performance of this inference method, by using linear and non linear statistical similarity measures. We find that, under adequate conditions, the network links can be perfectly inferred, i.e., no mistakes are made regarding the presence or absence of links. These conditions for perfect inference require: i) an appropriated choice of the observed variable to be analysed, ii) an appropriated interaction strength, and iii) an adequate thresholding of the similarity matrix. For the dynamical units considered here we find that the linear statistical similarity measure performs, in general, better than the non-linear ones.",,"Record Owner: From MEDLINE, a database of the U.S. National Library of Medicine.; Status: In-Data-Review; Publishing Model: Journal available in: Electronic Citation processed from: Internet; NLM Journal Code: 101563288; Other ID: Source: NLM. PMC4455306",,,,"10.1038/srep10829",,"2045-2322; 2045-2322","http://hdl.handle.net/20.500.12104/37391","http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=26042395",,"English",,,,,,"Scientific Reports",,"10829",,"5",,"MEDLINE",,,,"Index Medicus",,,,,,,,"Inferring the connectivity of coupled oscillators from time-series statistical similarity analysis.",,"Journal Article" "39171","123456789/35008",,"Vazquez-Del Mercado,Monica. Instituto de Biologia Molecular en Medicina, Universidad de Guadalajara, Jalisco, Mexico. bestvme@standford.edu",,"Vazquez-Del Mercado M

García-Gonzalez A

Munoz-Valle JF

García-Iglesias T

Martinez-Bonilla G

Bernard-Medina G

Sanchez-Ortiz A

Ornelas-Aguirre JM

Salazar-Paramo M

Gamez-Nava JI

Gonzalez-Lopez L",,"2002",,"OBJECTIVE: To evaluate cytokine production and cellular proliferation index (CPI) in peripheral blood mononuclear cells (PBMC) of patients with ankylosing spondylitis (AS), and their association with clinical variables. METHODS: In a cross sectional study we compared the production of tumor necrosis factor-alpha (TNF-alpha), interleukin 1beta (IL-1beta), and IL-10 and CPI in response to phytohemagglutinin (PHA) in PBMC of 27 patients with AS and 24 healthy controls. We also assessed clinical characteristics including disease activity index (BASDAI) and functional index (BASFI). RESULTS: Levels of IL-1beta were higher in patients with AS (median 242 pg/ml) than in controls (median 65 pg/ml); p = 0.002. No differences were observed in median levels of TNF-alpha or IL-10 between AS and controls. Patients had a reduction in CPI (1.2 in AS vs 1.8 in controls; p < 0.001). A positive correlation was observed between IL-10 production and age (rho = 0.34, p = 0.01). A borderline negative correlation was observed between CPI and age (rho = -0.26, p = 0.07). CONCLUSION: Patients with AS had high production of IL-1beta compared with controls and a poor response in CPI. These findings may explain the lack of response for microbial antigens mediated by the innate immune response.",,"Record Owner: From MEDLINE, a database of the U.S. National Library of Medicine.; Status: MEDLINE; Publishing Model: Journal available in: Print Citation processed from: Print; NLM Journal Code: 7501984, jwx; Registry Number/Name of Substance: 0 (Cytokines). 0 (Interleukin-1). 0 (Tumor Necrosis Factor-alpha). 130068-27-8 (Interleukin-10).; Entry Date: 20020924",,,,,,"0315-162X; 0315-162X","http://hdl.handle.net/20.500.12104/37392","http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med4&AN=11908566",,"English",,,,"3",,"Journal of Rheumatology",,"522

526",,"29",,"MEDLINE

WOS",,,,"Index Medicus;Adolescent;Adult;Cell Division/im [Immunology];Cross-Sectional Studies;Cytokines/an [Analysis];Humans;Interleukin-1/an [Analysis];Interleukin-10/an [Analysis];Leukocytes, Mononuclear/ch [Chemistry];Leukocytes, Mononuclear/cy [Cytology];Leukocytes, Mononuclear/im [Immunology];Middle Aged;Severity of Illness Index;Spondylitis, Ankylosing/im [Immunology];Tumor Necrosis Factor-alpha/an [Analysis]",,,,,,,,"Interleukin 1beta (IL-1beta), IL-10, tumor necrosis factor-alpha, and cellular proliferation index in peripheral blood mononuclear cells in patients with ankylosing spondylitis.",,"Journal Article" "39172","123456789/35008",,"Villalvazo Naranjo, Juan Universidad de Guadalajara",,"Villalvazo Naranjo, Juan Universidad de Guadalajara",,"2004",,,,,,,,,,"0185-0849","http://hdl.handle.net/20.500.12104/37393",,,"Español",,,,"330",,"Economía informa",,"40-54",,,,"CLASE",,,,,,,,"Tecnología de la información",,,,"Aplicación de las tecnologías de la información y las comunicaciones a las empresas",,"journalArticle" "39173","123456789/35008",,"Vasquez Garibay,E. Instituto de Nutricion Humana, Hospital Civil Dr. Juan L Menchaca, Universidad de Guadalajara, Jalisco, Mexico.",,"Vasquez Garibay E

Santos Torres I

Nelson SE

Ziegler EE

Rogers RR

Janghorbani M

Fomon SJ",,"2001",,"OBJECTIVE: In infants and children recovering from severe malnutrition, iron deficiency is common, and the ability to absorb iron during such recovery is uncertain. The objective of this study was to determine iron absorption during recovery from malnutrition. METHODS: During the later stages of recovery from malnutrition, erythrocyte incorporation of orally administered 58Fe was determined as a surrogate for iron absorption. Based on four indices, subjects were classified as iron-sufficient, iron-deficient or indeterminate. RESULTS: Of the 25 subjects, 9 were classified as iron sufficient, 5 as indeterminate and 11 as iron deficient; all but 5 had evidence of inflammation or infection. Geometric mean erythrocyte incorporation of 58Fe was 32.0% of the dose in the iron-deficient subjects, which was not significantly different (p = 0.073) than the 13.1% in the iron-sufficient subjects. Incorporation of 58Fe by the iron-sufficient subjects did not differ significantly from that by normal subjects in the same age range. Surprisingly, we found no correlation of erythrocyte incorporation of 58Fe and reticulocyte count. CONCLUSIONS: Even in the presence of infection or inflammation, iron absorption by children during a late stage of recovery from malnutrition is not impaired.",,"Record Owner: From MEDLINE, a database of the U.S. National Library of Medicine.; Status: MEDLINE; Publishing Model: Journal available in: Print Citation processed from: Print; NLM Journal Code: h51, 8215879; Registry Number/Name of Substance: 0 (Iron Isotopes). E1UOL152H7 (Iron).; Grant Number: HD 07578 (United States NICHD NIH HHS); Entry Date: 20011213",,,,,,"0731-5724; 0731-5724","http://hdl.handle.net/20.500.12104/37394","http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med4&AN=11506056",,"English",,,,"4",,"Journal of the American College of Nutrition",,"286

292",,"20",,"MEDLINE

WOS",,,,"Index Medicus;Absorption;Body Height;Body Weight;Child, Preschool;Cohort Studies;Erythrocytes/me [Metabolism];Female;Humans;Infant;Iron/bl [Blood];Iron/df [Deficiency];Iron/pk [Pharmacokinetics];Iron Isotopes;Male;Nutrition Disorders/me [Metabolism];Nutrition Disorders/th [Therapy];Reticulocyte Count",,,,,,,,"Iron absorption during recovery from malnutrition.",,"Journal Article" "39174","123456789/35008",,"Zanin,Massimiliano. Faculdade de Ciencias e Tecnologia, Departamento de Engenharia Electrotecnica, Universidade Novade Lisboa, Portugal. massimiliano.zanin@ctb.upm.es. Papo,David. Centre for Biomedical Technology, Polytechnic University of Madrid Pozuelo de Alarcon, 28223 Madrid, Spain. papodav@gmail.com. Solis,Jose Luis Gonzalez. Biophysics and Biological Science Laboratory, Centro Universitario de los Lagos, Universidad de Guadalajara, 47460, Lagos de Moreno, Jalisco, Mexico. jluis0968@gmail.com. Espinosa,Juan Carlos Martinez. Biophysics and Biological Science Laboratory, Centro Universitario de los Lagos, Universidad de Guadalajara, 47460, Lagos de Moreno, Jalisco, Mexico. jcmartineze@ipn.mx. Frausto-Reyes,Claudio. Centro de Investigaciones en Optica, A. C. 20200, Aguascalientes, Mexico. cfraus@cio.mx. Anda,Pascual Palomares. Hospital Regional de Alta Especializacion del Bajio 37660, Leon, Gto., Mexico. ppalomares61@hotmail.com. Sevilla-Escoboza,Ricardo. Biophysics and Biological Science Laboratory, Centro Universitario de los Lagos, Universidad de Guadalajara, 47460, Lagos de Moreno, Jalisco, Mexico. Jaimes-Reategui,Rider. Biophysics and Biological Science Laboratory, Centro Universitario de los Lagos, Universidad de Guadalajara, 47460, Lagos de Moreno, Jalisco, Mexico. Boccaletti,Stefano. Centre for Biomedical Technology, Polytechnic University of Madrid Pozuelo de Alarcon, 28223 Madrid, Spain. stefano.boccaletti@gmail.com. Menasalvas,Ernestina. Centre for Biomedical Technology, Polytechnic University of Madrid Pozuelo de Alarcon, 28223 Madrid, Spain. ernestina.menasalvas@upm.es. Sousa,Pedro. Faculdade de Ciencias e Tecnologia, Departamento de Engenharia Electrotecnica, Universidade Novade Lisboa, Portugal. pas@fct.unl.pt.",,"Zanin M

Papo D

Solis JL

Espinosa JC

Frausto-Reyes C

Anda PP

Sevilla-Escoboza R

Jaimes-Reategui R

Boccaletti S

Menasalvas E

Sousa P",,"2013",,"In the last decade, complex networks have widely been applied to the study of many natural and man-made systems, and to the extraction of meaningful information from the interaction structures created by genes and proteins. Nevertheless, less attention has been devoted to metabonomics, due to the lack of a natural network representation of spectral data. Here we define a technique for reconstructing networks from spectral data sets, where nodes represent spectral bins, and pairs of them are connected when their intensities follow a pattern associated with a disease. The structural analysis of the resulting network can then be used to feed standard data-mining algorithms, for instance for the classification of new (unlabeled) subjects. Furthermore, we show how the structure of the network is resilient to the presence of external additive noise, and how it can be used to extract relevant knowledge about the development of the disease.",,"Record Owner: From MEDLINE, a database of the U.S. National Library of Medicine.; Status: PubMed-not-MEDLINE; Publishing Model: Journal available in: Electronic Citation processed from: Print; NLM Journal Code: 101578790; Other ID: Source: NLM. PMC3901251; Entry Date: 20140624",,,,"10.3390/metabo3010155",,"2218-1989; 2218-1989","http://hdl.handle.net/20.500.12104/37395","http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=24957895",,"English",,,,"1",,"Metabolites",,"155

167",,"3",,"MEDLINE",,,,,,,,,,,,"Knowledge discovery in spectral data by means of complex networks.",,"Journal Article" "39175","123456789/35008",,"Guerrerosantos,Jose. Graduate School of the University Center of Health Sciences, Jalisco Plastic and Reconstructive Surgery Institute, University of Guadalajara, Guadalajara, Mexico, USA.",,"Guerrerosantos,J.",,"2008",,"The author demonstrates his method of achieving optimal contour in the aging neck. Primary features of the technique are horizontal cuts in the vertical bands of the platysma muscle combined with a corset Z-plasty medial suture and bilateral rein plication suture. This combined procedure, which effectively lifts the sagging neck, is useful in treating vertical platysma bands in primary cases, as well as recurrent platysma bands.",,"Record Owner: From MEDLINE, a database of the U.S. National Library of Medicine.; Status: MEDLINE; Publishing Model: Journal available in: Print Citation processed from: Internet; NLM Journal Code: 9707469; Entry Date: 20090223",,,,"10.1016/j.asj.2007.12.006",,"1527-330X; 1090-820X","http://hdl.handle.net/20.500.12104/37396","http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med5&AN=19083530",,"English",,,,"2",,"Aesthetic Surgery Journal",,"211

216",,"28",,"MEDLINE",,,,"Index Medicus;Aged;Facial Muscles/su [Surgery];Female;Humans;Middle Aged;Neck Muscles/su [Surgery];Physical Examination/mt [Methods];Rejuvenation;Rhytidoplasty/mt [Methods]",,,,,,,,"Managing platysma bands in the aging neck.",,"Journal Article" "39176","123456789/35008",,"Cid-Hernandez,Margarita. Departamento de Quimica, Centro Universitario de Ciencias Exactas e Ingenierias, Universidad de Guadalajara, Blvd. Marcelino García Barragan 1421, 44430, Guadalajara, Jalisco, Mexico. sagitario_garita_mar@hotmail.com. Ramirez-Anguiano,Ana C. Departamento de Quimica, Centro Universitario de Ciencias Exactas e Ingenierias, Universidad de Guadalajara, Blvd. Marcelino García Barragan 1421, 44430, Guadalajara, Jalisco, Mexico. anacristina.ramirezanguiano@gmail.com. Ortiz,Genaro G. Division de Neurociencias, Laboratorio de Desarrollo, Envejecimiento y Enfermedades Neurodegenerativas, Centro de Investigacion Biomedica de Occidente (CIBO), Instituto Mexicano del Seguro Social (IMSS), Sierra Mojada 800, 44340, Guadalajara, Jalisco, Mexico. genarogabriel@yahoo.com. Morales-Sanchez,Eddic W. Division de Neurociencias, Laboratorio de Desarrollo, Envejecimiento y Enfermedades Neurodegenerativas, Centro de Investigacion Biomedica de Occidente (CIBO), Instituto Mexicano del Seguro Social (IMSS), Sierra Mojada 800, 44340, Guadalajara, Jalisco, Mexico. ew820510@gmail.com. Gonzalez-Ortiz,Luis J. Departamento de Quimica, Centro Universitario de Ciencias Exactas e Ingenierias, Universidad de Guadalajara, Blvd. Marcelino García Barragan 1421, 44430, Guadalajara, Jalisco, Mexico. ljglez@yahoo.com.mx. Velasco-Ramirez,Sandra F. Departamento de Quimica, Centro Universitario de Ciencias Exactas e Ingenierias, Universidad de Guadalajara, Blvd. Marcelino García Barragan 1421, 44430, Guadalajara, Jalisco, Mexico. sandra@gmail.com. Pacheco-Moises,Fermin P. Departamento de Quimica, Centro Universitario de Ciencias Exactas e Ingenierias, Universidad de Guadalajara, Blvd. Marcelino García Barragan 1421, 44430, Guadalajara, Jalisco, Mexico. ferminpacheco@hotmail.com.",,"Cid-Hernandez M

Ramirez-Anguiano AC

Ortiz GG

Morales-Sanchez EW

Gonzalez-Ortiz LJ

Velasco-Ramirez SF

Pacheco-Moises FP",,"2015",,"BACKGROUND: Karwinskia humboldtiana (Kh) is a poisonous plant of the rhamnacea family. To elucidate some of the subcellular effects of Kh toxicity, membrane fluidity and ATPase activities as hydrolytic and as proton-pumping activity were assessed in rat liver submitochondrial particles. Rats were randomly assigned into control non-treated group and groups that received 1, 1.5 and 2 g/Kg body weight of dry powder of Kh fruit, respectively. Rats were euthanized at day 1 and 7 after treatment. RESULTS: Rats under Kh treatment at all dose levels tested, does not developed any neurologic symptoms. However, we detected alterations in membrane fluidity and ATPase activity. Lower dose of Kh on day 1 after treatment induced higher mitochondrial membrane fluidity than control group. This change was strongly correlated with increased ATPase activity and pH gradient driven by ATP hydrolysis. On the other hand, membrane fluidity was hardly affected on day 7 after treatment with Kh. Surprisingly, the pH gradient driven by ATPase activity was significantly higher than controls despite an diminution of the hydrolytic activity of ATPase. CONCLUSIONS: The changes in ATPase activity and pH gradient driven by ATPase activity suggest an adaptive condition whereby the fluidity of the membrane is altered.",,"Record Owner: From MEDLINE, a database of the U.S. National Library of Medicine.; Status: In-Process; Publishing Model: Journal available in: Electronic Citation processed from: Internet; NLM Journal Code: bsa, 9308271; Other ID: Source: NLM. PMC4376499",,,,"10.1186/s40659-015-0008-9",,"0717-6287; 0716-9760","http://hdl.handle.net/20.500.12104/37397","http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=25889629",,"English",,,,"1",,"Biological research",,"17",,"48",,"MEDLINE

ScIELO",,,,"Index Medicus",,,,,,,,"Mitochondrial ATPase activity and membrane fluidity changes in rat liver in response to intoxication with buckthorn (Karwinskia humboldtiana).",,"Journal Article" "39177","123456789/35008",,"Ramia,Jose M. Department of Hepatopancreatobiliary (HPB) Surgery, Guadalajara University Hospital, Guadalajara, Spain. jose_ramia@hotmail.com",,"Ramia JM

Lopez-Andujar R

Torras J

Falgueras L

Gonzalez JA

Sanchez B

Figueras J",,"2011",,"OBJECTIVES: Resection of colorectal cancer (CRC) liver metastases (LM) in pathological liver (PL) patients (with cirrhosis or hepatopathy) is extremely rare. The aim of this study was to perform a multicentre, retrospective analysis of epidemiology, surgical techniques and outcomes in patients with PL who underwent hepatic resection for CRC-LM. METHODS: A retrospective, multicentre questionnaire was distributed to 15 hepatopancreatobiliary surgical units. RESULTS: Only six of 15 (40%) HPB units reported any experience in the surgical resection of CRC-LM in patients with PL. Of the 20 patients identified, 10 had underlying cirrhosis and 10 had chronic hepatopathy. Their median age was 66 years (range: 49-81 years). Thirteen patients were male. Liver dysfunction was known preoperatively in 18 patients. All patients had Child-Pugh class A disease. Six patients had synchronous disease. There were a total of 38 lesions among the 20 patients, distributed at a median of one lesion per patient (range: 1-4 lesions). The median size of the lesions was 3.0 cm (range: 1.5-9.0 cm). Preoperative median carcinoembryonic antigen (CEA) was 32.3 ng/ml (range: 1-184 ng/ml). The surgical procedures performed included: sub-segmentectomy (n= 12); left lateral sectionectomy (n= 6); segmentectomy (n= 4); radiofrequency ablation (n= 3), and exploratory laparotomy (n= 4). Morbidity occurred in four patients (Clavien grades I [n= 1], II [n= 2] and IVa [n= 1]). Mortality was nil. An R0 resection margin was achieved in 15 of 16 patients. Twelve patients did not receive chemotherapy. In resected patients, 10 presented with relapse. The median disease-free and overall survival periods were 12.2 and 22.3 months, respectively. CONCLUSIONS: When feasible, liver resection is the best option for CRC-LM in PL patients.Copyright ?" 2011 International Hepato-Pancreato-Biliary Association.