Article
Optimizing outcomes in multiple sclerosis: Consensus guidelines for the diagnosis and treatment of multiple sclerosis in Latin America
Fecha
2010Autor
Mendoza-Carrera, F.
Ramirez-Lopez, G.
Ayala-Martinez, N.A.
García-Zapien, A.G.
Flores-Martinez, S.E.
Sanchez-Corona, J.
Institución
Resumen
Background and Aims: Obesity correlates with a chronic and low-grade inflammation status. C-reactive protein (CRP) measurement has been used as an independent risk marker for future cardiovascular events. CRP level shows interindividual variability due to environmental and genetic factors. The aim of this study was to assess the association of functional polymorphisms on CRP, IL6, and TNFA genes with serum CRP levels in Mexican mestizo adolescents. Methods: Body mass index (BMI), serum high-sensitivity C-reactive protein (hsCRP) levels, and genotypes for CRP+1444C>T, IL6-174G>C, and TNFA-308G>A polymorphisms were obtained from 418 unrelated Mexican adolescents. Genetic association with hsCRP levels was evaluated by means of a dominant genetic model with uni- and multivariate analysis. Results: Genotype frequencies for all three polymorphisms were according to Hardy-Weinberg equilibrium (HWE). CRP+1444T, TNFA-308A, and IL6-174C allele frequencies were 37, 7, and 10%, respectively. CRP+1444T was associated with higher mean CRP levels independent of age, gender and BMI (? = 0.21; 95% confidence interval [95% CI] = 0.02-0.39); p = 0.030). IL6-174C was associated with low CRP levels in the overweight group (p = 0.005). IL6-174G>C and TNFA-308G>A allele frequencies observed from this Mexican sample were similar to data for other Mexican populations. Conclusions: The CRP+1444C>T polymorphism was associated with CRP levels in Mexican adolescents and could be used as a genetic marker for the early detection of individuals at risk for developing obesity-related conditions such as cardiovascular disease or type 2 diabetes mellitus in early adulthood. " 2010 IMSS.",,,,,,"10.1016/j.arcmed.2010.08.015",,,"http://hdl.handle.net/20.500.12104/42225","http://www.scopus.com/inward/record.url?eid=2-s2.0-78049450700&partnerID=40&md5=8bf85f9936fecce0eb8b42b6536621e3",,,,,,"6",,"Archives of Medical Research",,"472 477",,"41",,"Scopus WOS",,,,,,"Adolescents; CRP levels; Cytokine polymorphisms; Inflammation; Obesity; Overweight",,,,,,"Influence of CRP, IL6, and TNFA Gene Polymorphisms on Circulating Levels of C-Reactive Protein in Mexican Adolescents",,"Article"
"43997","123456789/35008",,"Alatorre-Zamora, M.A., Departamento de Ingeniería Civil y Topografía, Centro Universitario de Ciencias Exactas e Ingeniería, Universidad de Guadalajara, Mexico; Campos-Enríquez, J.O., Instituto de Geofísica, Universidad Nacional Autónoma de México, Delegación Coyoacán, 04510, México D.F, Mexico; Belmonte-Jiménez, S., Centro Interdisciplinario de Investigación para, Desarrollo Integral Regional Unidad Oaxaca, Mexico; Ibarra-Nuño, J., Departamento de Física, Universidad de Guadalajara, Mexico",,"Alatorre-Zamora, M.A. Campos-Enriquez, J.O. Belmonte-Jimenez, S. Ibarra-Nuno, J.",,"2014",,"We used the VLF technique to infer fault or major fracture zones that might serve as path for contaminant waste fluids in the Matatlan dumpsite, in Guadalajara, western Mexico. To interpret the data we used the Fraser, and Karous-Hjelt filters. Profiles were interpreted with 2D direct modeling based on Karous-Hjelt modified filter (K-H). The Fraser and Karous-Hjelt conjugated filter were applied to the entire data. The results of both techniques show similarities in the directions and positions of anomalous features, which are assumed fault or fracture zones. We observed one fault zone at the centre of the site, with a NEE-SWW strike. Other important inferred structures have NW-SE directions at the western part of the site. The cooperative use of both techniques, based on K-H filter and the Fraser filter give results as an N-S inferred structure in the westernmost part of the zone, as well as NW-SE linear anomalies, mainly in the western half of the site. The N-S structure has the same direction as that of Rio Grande de Santiago Canyon. The NW-SE features coincide with the directions of the Tepic-Zacoalco rift. Others NE-SW lineaments are located towards the centre of the area. These facts coincide strongly with the predominance of fracture groups show in the fracture analysis. The inferred structures could serve as conduits for the leachates to migrate towards the Coyula canyon as well as towards the Rio Grande de Santiago Canyon. Statistic analysis of fracture orientations showed N-S (A), N75-80E (B), N60-65W (C), and N25-30W (D) main directions, and N45-55E (E), and 90E (F) secondary directions. Group A coincides with the direction of the Rio Grande de Santiago Canyon, whereas pattern F have the same direction as Coyula Canyon.",,,,,,,,,"http://hdl.handle.net/20.500.12104/42218","http://www.scopus.com/inward/record.url?eid=2-s2.0-84903638393&partnerID=40&md5=5ba3825c6a280584bb3d14e6e1b61f22",,,,,,"3",,"Geofisica Internacional",,"241 257",,"53",,"Scopus WOS",,,,,,"Current distribution; Fracture zones; Fraser and karous-Hjelt filters; Matatlan dumpsite; Very low frequency",,,,,,"Inference of fault and fracture systems beneath the Matatlan waste dump basement, a VLF study",,"Article"
"43989","123456789/35008",,"Zavala-Aguirre, J.L., Escuela de Biología, Universidad Autónoma de Guadalajara, Guadalajara, Mexico; Torres-Bugarín, O., Programa Internacional, Facultad de Medicina, Universidad Autonoma de Guadalajara, Guadalajara, Mexico; Buelna-Osben, H.R., Centro Interdisciplinario de Investigación Para El Desarrollo Integral Regional, Michoacán, Mexico; Flores-Kehn, L.P., Escuela de Biología, Universidad Autónoma de Guadalajara, Guadalajara, Mexico; Ramos-Ibarra, M.L., Departamento de Salud Pública, División de Ciencias Veterinarias, Centro Universitario de Ciencias Biologicas y Agropecuarias, Guadalajara, Mexico; Zúñiga-González, G., Laboratorio de Mutagénesis, Centro de Investigación Biomédica de Occidente Del IMSS, Guadalajara, Mexico; Ogura, T., Departamento de Química, Universidad Autónoma de Guadalajara, Guadalajara, Mexico",,"Zavala-Aguirre, J.L. Torres-Bugarin, O. Buelna-Osben, H.R. Flores-Kehn, L.P. Ramos-Ibarra, M.L. Zuniga-Gonzalez, G. Ogura, T.",,"2010",,"This study is a follow-up of previous research in which we described the frequency of spontaneous micronucleated erythrocytes (MNE) in the Goodeid Xenotocoa melanosoma collected from Lake La Alberca, located in the state of Michoacan, México. In the present work, we measured micronuclei (MN) and nuclear abnormalities (NA) in erythrocytes of peripheral blood. Bioassays taken at 24 or 96 hours in either the cyclophosfamide (CP) or colchicine (COL) showed a significant increase in MN and BC (P values ranging from 0.0499 to 0.0036) compared with information from wild organisms collected over 3 years. Concentrationdependent and time-dependent responses support the proposal of using endemic Xenotoca melanosoma as a bioindicator of genotoxicity and cytotoxicity with a high transcendence for the health of the entire ecosystem and evaluation of the Lerma-Chapala watershed.",,,,,,"10.1080/10934520903388863",,,"http://hdl.handle.net/20.500.12104/42210","http://www.scopus.com/inward/record.url?eid=2-s2.0-77649295765&partnerID=40&md5=fe0d9ac5bf824bca26ca37379f09a762",,,,,,"1",,"Journal of Environmental Science and Health - Part A Toxic/Hazardous Substances and Environmental Engineering",,"75 81",,"45",,"Scopus WOS",,,,,,"Bioindicator; Colchicine; Cyclophosphamide; Nuclear abnormalities; Peripheral blood erythrocytes; Spontaneous micronuclei; Xenotoca melanosoma",,,,,,"Induction of micronuclei and nuclear abnormalities by cyclophosphamide and colchicine in Xenotoca melanosoma (Pisces, Goodeidae) from Lake la Alberca in Michoacán, México",,"Conference Paper"
"45181","123456789/35008",,"Carr , A., Multiple Sclerosis Section, Hospital Británico de Buenos Aires, Caba, Argentina; Macías-Islas, M.A., Departamento de Neurociencias, CUCS UdeG, Mexico; Gabbai, A.A., Department of Neurology, Paulista School of Medicine Federal, University of Sao Paulo, Sao Paulo, Brazil; Correale, J., Department of Neurology, Institute for Neurological Research, Dr. Raúl Carrea FLENI, Caba, Argentina; Bolaña, C., Department of Neurology Service, Center Pasteur Hospital, Montevideo, Uruguay; Sotelo, E.D., Departamento de Neurología, Unidad Médica de Altas Especialidades de Monterrey, Monterrey, NL, Mexico; Bonitto, J.G., Clínica de Marly Bogotá, Colombia; Vergara-Edwards, F., Instituto de Neurociencias, Facultad de Medicina, Universidad Del Desarrollo, Santiago de Chile, Chile; Vizcarra-Escobar, D., Universidad Peruana Cayetano Heredia Hypnos, Instituto Del Sueño, Clinica San Felipe, Lima, Peru",,"Carra, A. MacIas-Islas, M.A. Gabbai, A.A. Correale, J. Bolana, C. Sotelo, E.D. Bonitto, J.G. Vergara-Edwards, F. Vizcarra-Escobar, D.",,"2011",,"Objective: The prevalence of multiple sclerosis (MS) in Latin America varies across different studies but an intermediate risk and increased frequency of the disease have been reported in recent years. The circumstances of Latin American countries are different from those of Europe and North America, both in terms of differential diagnoses and disease management.Methods: An online survey on MS was sent to 855 neurologists in nine Latin American countries. A panel of nine experts in MS analyzed the results.Results: Diagnostic and therapeutic recommendations were outlined with special emphasis on the specific needs and circumstances of Latin America. The experts proposed guidelines for MS diagnosis, treatment, and follow up, highlighting the importance of considering endemic infectious diseases in the differential diagnoses of MS, the identification of patients at high risk of developing MS in order to maximize therapeutic opportunities, early treatment initiation, and cost-effective control of treatment efficacy, as well as global assessment of disability.Conclusions: The experts recommended that healthcare systems allocate a longer consultation time for patients with MS, which must be conducted by neurologists trained in the management of the disease. All drugs currently approved must be available in all Latin American countries and must be covered by healthcare plans. The expert panel supported the creation of a permanent forum to discuss future clinical and therapeutic recommendations that may be useful in Latin American countries. " SAGE Publications 2011.