Measuring the profile of a simulated machined aspherical surface using a nonconventional optimization algorithm

Abstract

To understand the precise disease driving mechanisms in acute myeloid leukemia (AML), comparison of patient matched hematopoietic stem cells (HSC) and leukemia stem cells (LSC) is essential. In this analysis, we have examined the value of aldehyde dehydrogenase (ALDH) activity in combination with CD34 expression for the separation of HSC from LSC in 104 patients with de novo AML. The majority of AML patients (80 out of 104) had low percentages of cells with high ALDH activity (ALDH(+) cells; 1.9%; ALDH-numerous AML). In patients with ALDH-rare AML, normal HSC could be separated by their CD34(+) ALDH(+) phenotype, whereas LSC were exclusively detected among CD34(+) ALDH(-) cells. For patients with ALDH-numerous AML, the CD34(+) ALDH(+) subset consisted mainly of LSC and separation from HSC was not feasible. Functional analyses further showed that ALDH(+) cells from ALDH-numerous AML were quiescent, refractory to ARA-C treatment and capable of leukemic engraftment in a xenogenic mouse transplantation model. Clinically, resistance to chemotherapy and poor long-term outcome were also characteristic for patients with ALDH-numerous AML providing an additional risk-stratification tool. The difference in spectrum and relevance of ALDH activity in the putative LSC populations demonstrates, in addition to phenotypic and genetic, also functional heterogeneity of leukemic cells and suggests divergent roles for ALDH activity in normal HSC versus LSC. By acknowledging these differences our study provides a new and useful tool for prospective identification of AML cases in which separation of HSC from LSC is possible. Copyright " 2014 UICC.",,"Record Owner: From MEDLINE, a database of the U.S. National Library of Medicine.; Status: In-Data-Review; Publishing Model: Journal available in: Print-Electronic Citation processed from: Internet; NLM Journal Code: gqu, 0042124; Keyword Heading: acute myeloid leukemia aldehyde dehydrogenase hematopoietic stem cell high risk factor leukemia stem cell",,,,"10.1002/ijc.29410",,"1097-0215; 0020-7136","http://hdl.handle.net/20.500.12104/37429","http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=25545165",,"English",,,,"3",,"International Journal of Cancer",,"525

536",,"137",,"MEDLINE",,,,"Index Medicus",,,,,,,,"The rarity of ALDH(+) cells is the key to separation of normal versus leukemia stem cells by ALDH activity in AML patients.",,"Journal Article" "39199","123456789/35008",,"Pozos-Radillo,Elizabeth. Health Sciences Centre, University of Guadalajara, Jalisco, Mexico. Preciado-Serrano,Lourdes. Health Sciences Centre, University of Guadalajara, Jalisco, Mexico. Plascencia,Ana R. Health Sciences Centre, University of Guadalajara, Jalisco, Mexico. Carrion-García,Ma. Universitat Oberta Cataluya, Barcelona, Spain. de Los A Aguilera,Maria. Health Sciences Centre, University of Guadalajara, Jalisco, Mexico.",,"Pozos-Radillo E

Preciado-Serrano L

Plascencia AR

Carrion-García M

de Los A Aguilera M",,"2015",,"UNLABELLED: Social representations are a type of common sense knowledge shared by different groups based on their experience. This study identified the social representations of dental practice in a group of environmental health graduate students in Lima, Peru. METHOD: We interviewed 25 graduate students using a "focus group" technique and a semi-structured guide. Three groups were formed with purposive sampling. The data were collected during the years 2010-2011, and analyzed using open, axial, selective coding with Atlas-Ti software. RESULTS: Three substantive categories were identified: dental practice, characteristics of the dental care provider and dental practice setting. The social representations that the students identified with dental practice were fear and pain. CONCLUSIONS: The negative social representations of dental practice may affect viability and adherence to treatment, so it is important to identify them in time in order to intervene effectively.",,"Record Owner: From MEDLINE, a database of the U.S. National Library of Medicine.; Status: In-Data-Review; Publishing Model: Journal available in: Print Citation processed from: Print; NLM Journal Code: act, 8610218; Publisher Item Identifier: S1852-48342015000100005",,,,"10.1590/S1852-48342015000100005",,"0326-4815; 0326-4815","http://hdl.handle.net/20.500.12104/37420","http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=prem&AN=25950161",,"English",,,,"1",,"Acta Odontologica Latinoamericana",,"35

41",,"28",,"MEDLINE",,,,,,,,,,,,"Social representat ions of dental treatment in a group of environmental health graduate students in Lima (Peru).",,"Journal Article" "39224","123456789/35008",,,"Navarro Ochoa, Angélica",,"2010",,"Este trabajo aborda las circunstancias que han posibilitado el surgimiento de "jefaturas femeninas" en los hogares de dos localidades del municipio de Santiago Tangamandapio, Michoacán. Muestra cómo las mujeres de estos lugares lograron una visibilidad y un protagonismo que, en muchos casos, no es percibido por ellas mismas; y valora cómo la participación laboral de las mujeres y su aporte al hogar se ha extendido gracias a los cambios en las representaciones del ser y hacer femenino, pues ellas ya no sólo se dedican al hogar y al cuidado de los hijos, sino que están construyendo otras representaciones de mujer: trabajadora, líder o jefa de familia.",,,,,,,,"1405-9436",,"http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S1405-94362010000100007&lng=es&nrm=iso&tlng=es; http://132.248.9.1:8991/F/T2YHQN5JKYSPCIP3SAPK3TB1KGTDDEFCSVNH496MXCXGEJUB2B-02695?func=full-set-set&set_number=025047&set_entry=000423&format=999

http://hdl.handle.net/20.500.12104/37445",,"Español",,,,"31",,"Revista de estudios de género",,"139

717",,"4",,"PERIODICA

CLASE",,,,"Sociología de la mujer",,,,,,"¿Mujeres proveedoras y jefas de familia? ...Nuevas realidades rurales en localidades de la región zamorana","¿Mujeres proveedoras y jefas de familia?",,,"journalArticle", "39204","123456789/35008",,"Lizcano-Gil,L A. Maestria en Gentica Humana, Universidad de Guadalajara, Jalisco, Mexico.",,"Lizcano-Gil LA

García-Cruz D

Cantu JM

Fryns JP",,"1994",,"The Aarskog syndrome is a true MCA syndrome with X-linked recessive inheritance. The clinical phenotype, and its evolution with age, have been well documented in the past. Few data are reported on the radiological skeletal changes and findings. The purpose of the present paper is to describe the clinical and radiological findings in two brothers with Aarskog syndrome and to further delineate the radiological characteristics of this condition. The main findings are asynchronic and delayed bone age, shortened long tubular bones with wide metaphyses, brachyphalangy, hypoplasia of the middle phalanges of the fifth fingers, short and broad first metacarpals and metatarsals and pelvic hypoplasia.",,"Record Owner: From MEDLINE, a database of the U.S. National Library of Medicine.; Status: MEDLINE; Publishing Model: Journal available in: Print Citation processed from: Print; NLM Journal Code: aiv, 9015261; Entry Date: 19950420",,,,,,"1015-8146; 1015-8146","http://hdl.handle.net/20.500.12104/37425","http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med3&AN=7888143",,"English",,,,"4",,"Genetic Counseling",,"387

392",,"5",,"MEDLINE",,,,"Index Medicus;Abnormalities, Multiple/ge [Genetics];Abnormalities, Multiple/ra [Radiography];Age Determination by Skeleton;Bone Diseases, Developmental/ge [Genetics];Bone Diseases, Developmental/ra [Radiography];Bone and Bones/ra [Radiography];Child, Preschool;Dwarfism/ge [Genetics];Dwarfism/ra [Radiography];Facial Bones/ab [Abnormalities];Facial Bones/ra [Radiography];Fingers/ab [Abnormalities];Fingers/ra [Radiography];Genes, Recessive/ge [Genetics];Genitalia, Male/ab [Abnormalities];Genitalia, Male/ra [Radiography];Humans;Male;Sex Chromosome Aberrations/ge [Genetics];Skull/ab [Abnormalities];Skull/ra [Radiography];Syndrome;X Chromosome",,,,,,,,"The facio-digito-genital syndrome (Aarskog syndrome): a further delineation of the distinct radiological findings.",,"Journal Article" "44491","123456789/35008",,"Tonneau, F., University of Guadalajara, Mexico, Centro de Estudios de Alcoholismo y Adicciones, Antigua Escuela de Medicina, Calle Hospital 320, 3er Piso, CP 44280, Guadalajara, Jalisco, Mexico; Ríos, A., University of Guadalajara, Mexico; Cabrera, F., University of Guadalajara, Mexico",,"Tonneau, F.

Rios, A.

Cabrera, F.",,"2006",,"Resistance to change is often studied by measuring response rate in various components of a multiple schedule. Response rate in each component is normalized (that is, divided by its baseline level) and then log-transformed. Differential resistance to change is demonstrated if the normalized, logtransformed response rate in one component decreases more slowly than in another component. A problem with normalization, however, is that it can produce artifactual results if the relation between baseline level and disruption is not multiplicative. One way to address this issue is to fit specific models of disruption to untransformed response rates and evaluate whether or not a multiplicative model accounts for the data. Here we present such a test of resistance to change, using within-session response patterns in rats as a data base for fitting models of disruption. By analyzing response rate at a withinsession level, we were able to confirm a central prediction of the resistance-to-change framework while discarding normalization artifacts as a plausible explanation of our results.",,,,,,"10.1901/jeab.2006.74-05",,,"http://hdl.handle.net/20.500.12104/42712","http://www.scopus.com/inward/record.url?eid=2-s2.0-33746253636&partnerID=40&md5=df221d2cc2841a386c67c0b18dc2ded5",,,,,,"1",,"Journal of the Experimental Analysis of Behavior",,"109

121",,"86",,"Scopus

WOS",,,,,,"Absolute rates; Lever press; Rats; Relative rates; Resistance to change; Within-session patterns",,,,,,"Measuring resistance to change at the within-session level",,"Article" "39217","123456789/35008",,,"Fregoso Centeno, Aanyanci",,"2004",,,,,,,,,,"1405-9436",,"http://148.202.18.157/sitios/publicacionesite/pperiod/laventan/Ventana20/Calladita%20te%20ves%20mas%20bonita%20(396-401).pdf; http://148.202.18.157/sitios/publicacionesite/pperiod/laventan/Ventana20/Calladita%20te%20ves%20mas%20bonita%20(396-401).pdf; http://132.248.9.1:8991/F/T2YHQN5JKYSPCIP3SAPK3TB1KGTDDEFCSVNH496MXCXGEJUB2B-13617?func=full-set-set&set_number=025047&set_entry=000889&format=999; http://132.248.9.1:8991/F/T2YHQN5JKYSPCIP3SAPK3TB1KGTDDEFCSVNH496MXCXGEJUB2B-13617?func=full-set-set&set_number=025047&set_entry=000889&format=999

http://hdl.handle.net/20.500.12104/37438",,"Español",,,,"20",,"Revista de estudios de género",,"397

401",,"20",,"PERIODICA

CLASE",,,,"Sociología de la mujer",,,,,,"¿Calladita te ves más bonita? Dresser, Denise (coord.). Gritos y susurros. Experiencias intempestivas de 38 mujeres. México: Grijalbo, 2004.","¿Calladita te ves más bonita?",,,"journalArticle", "39207","123456789/35008",,,"García de Alba García, R.",,"1995",,,,,,,,,,"0187-7674",,"http://hdl.handle.net/20.500.12104/37428",,"Español",,,,"43",,"Confines de relaciones internacionales y ciencia política",,"23-29",,"8",,"CLASE",,,,,,,,"Ecología",,"Aproximacion a la historia ambiental de la region de ciudad guzman",,,,"journalArticle", "44492","123456789/35008",,"Sánchez Escobar, J.J., Centro de Enseñanza Técnica Industrial (CETI), Nueva Escocia 1885, Fraccionamiento Providencia, Guadalajara, Jalisco 44620, Mexico, Universidad de Guadalajara, Campus Universitario de Los Valles, Carreterra Guadalajara meca km 45.5, Ameca, Jalisco, Mexico; Barbosa Santillán, L.I., Universidad Politécnica de Madrid, Facultad de Informética, Boadilla Del Monte, 28660 Madrid, Spain; Ubera, J.V., Universidad Autónoma de la Ciudad de México, Campus Cuautepec, Avenida la Corona No. 320, Col. Loma la palma, Delegacion Gustavo A Madero, 54060 Mexico, D.F., Mexico; Salinas-Luna, J., Universidad de Guadalajara, Campus Universitario de Los Valles, Carreterra Guadalajara meca km 45.5, Ameca, Jalisco, Mexico; Guillen-Bonilla, H., Universidad de Guadalajara, Departamento de Física CUCEI Blvd, Marcelino García Barragán 1421, Guadalajara, Jalisco, Mexico",,"Sanchez Escobar, J.J.

Barbosa Santillan, L.I.

Ubera, J.V.

Salinas-Luna, J.

Guillen-Bonilla, H.",,"2008",,"We show an optimization method based on an evolutive algorithm to obtain the profile of a simulated machined aspherical surface starting from a set of noisy discrete Cartesian coordinates (x,y,z), where the experimental coordinates x and y are used to simulate the sagitta z of the analyzed surface. By minimizing an objective function, the proposed method fits the sagitta function to the set of noisy discrete coordinates; thus the geometrical parameters of the simulated surface under test, such as the paraxial radius of curvature, the conic constant, and the aspheric deformation constants, can be obtained. Numerical results show that our method can be successfully applied to retrieve the simulated machined surface profile. " 2008 Society of Photo-Optical Instrumentation Engineers.