Article
International multicenter evaluation of autoantibodies to ribosomal P proteins
Fecha
2014Autor
Vidal, Z.E.O.
Rufino, S.C.
Tlaxcalteco, E.H.
Trejo, C.H.
Campos, R.M.
Meza, M.N.
Rodriguez, R.C.
Arroyo-Helguera, O.
Institución
Resumen
Iodine is an essential element trace for the synthesis of maternal thyroid hormones needed to support normal fetal development; it also acts as an antioxidant directly or induce antioxidant enzymes indirectly. Iodine deficiency and oxidative stress are associated with pregnancy complications. This study aimed to assess the urinary iodine concentration and its relationship with the antioxidant and oxidative stress status during gestation. Pregnant women were consecutively recruited from an obstetric clinic during all gestation trimesters, and urinary iodine concentration, antioxidant, and oxidative stress were determined. Results showed that 70 % of pregnant women have optimal iodine levels (150-200 ?g/L), while approximately 30 % showed mild iodine deficiency (50-99 ?g/L). Oxidative stress was significantly higher, and the antioxidant status was also compromised as evidenced by decreased total antioxidant status and superoxide dismutase (SOD) activity in pregnant women with mild iodine deficiency than pregnant women with optimal iodine levels. Significant positive correlations were noted between optimal iodine levels and total antioxidant status. Oxidative stress was significantly correlated with mild iodine deficiency. However, no significant correlation was found between iodine levels and SOD and catalase activities. In conclusion, for the first time, these data suggest a correlation between iodine levels and the antioxidant status during pregnancy. " 2014 Springer Science+Business Media New York.",,,,,,"10.1007/s12011-014-9898-6",,,"http://hdl.handle.net/20.500.12104/43455","http://www.scopus.com/inward/record.url?eid=2-s2.0-84896703059&partnerID=40&md5=04f3ec98af32b79ba0335f6aa75ad677",,,,,,"3",,"Biological Trace Element Research",,"211 217",,"157",,"Scopus WOS",,,,,,"Antioxidant status; Gestation; Iodine; Oxidative stress; Pregnant women",,,,,,"Oxidative stress increased in pregnant women with iodine deficiency",,"Article"
"44108","123456789/35008",,"Mahler, M., Dr. Fooke Laboratorien GmbH, Neuss, Germany, Dr. Fooke Laboratorien GmbH, Mainstr. 85, 41469 Neuss, Germany; Kessenbrock, K., Department of Molecular Genetics, University of Heidelberg, Heidelberg, Germany; Szmyrka, M., Wroclaw University of Medicine, Wroclaw, Poland; Takasaki, Y., Division of Rheumatology, Department of Medicine, Jutendo University, Tokyo, Japan; García-De La Torre, I., University of Guadalajara, Guadalajara, Mexico; Shoenfeld, Y., Sheba Medical Center, Tel Aviv, Israel; Hiepe, F., Charite Humboldt University, Berlin, Germany; Shun-Le, C., Shanghai Medical University, Shanghai, China; Von Mohlen, C.A., Pontifical Catholic University School of Medicine, Porto Allegre, Brazil; Locht, H., Statens Serum Institute, Copenhagen, Denmark; Hipfl, P., Sweden Diagnostics Deutschland GmbH, Freiburg, Germany; Wiik, A., Statens Serum Institute, Copenhagen, Denmark; Reeves, W., University of Florida, Gainesville, FL, United States; Fritzler, M.J., University of Calgary, Calgary, Alta., Canada",,"Mahler, M. Kessenbrock, K. Szmyrka, M. Takasaki, Y. García-De La Torre, I. Shoenfeld, Y. Hiepe, F. Shun-Le, C. Von Muhlen, C.A. Locht, H. Hopfl, P. Wiik, A. Reeves, W. Fritzler, M.J.",,"2006",,"Autoantibodies to the ribosomal phosphoproteins (Rib-F) are a serological feature of patients with systemic lupus erythematosus (SLE). The reported prevalence of anti-Rib-P antibodies in SLE ranges from 10 to 40%, being higher in Asian patients. The variation in the observed frequency may be related to a number of factors but is dependent in large part on the test system used to detect the autoantibodies. An association of anti-Rib-P with central nervous system involvement and neuropsychiatric manifestations of SLE has been controversial. In the present international multicenter study, we evaluated the clinical accuracy of a new sensitive Rib-P-specific enzyme-linked immunosorbent assay based on recombinant Rib-P polypeptides. The results showed that 21.3% of 947 SLE patients, but only 0.7% of 1,113 control patients, had a positive test result (P < 0.0001). The sensitivity, specificity, positive and negative predictive values, and diagnostic efficiency were determined to be 21.3%, 99.3%, 95.6%, 62.2%, and 65.3%, respectively. When evaluated in the context of participating centers, the prevalence of anti-Rib-P antibodies was found in descending frequency, as follows: China (35%) > Poland (34%) > Japan (28%) > United States (26%) > Germany (Freiburg; 23.3%) > Denmark (20.5%) > Germany (Berlin; 19%) > Mexico (15.7%) > Israel (11.7%) > Brazil (10%) > Canada (8%). The substantial data from this study indicate that the prevalence of anti-Rib-P antibodies may not be restricted to the genetic background of the patients or to the detection system but may depend on regional practice differences and patient selection. We confirm previously reported associations of antiribosomal antibodies with clinical symptoms and serological findings. Remarkably, we found a lower occurrence of serositis in Rib-P-positive lupus patients. Copyright " 2006, American Society for Microbiology. All Rights Reserved.