info:eu-repo/semantics/article
Epigenetic Approach on Colorectal Cancer Systemic Therapy: Promising yet a Long Way to Go
Autor
Ayu Rezkitha, Yudith Annisa
Aji Savitri, Camilia Metadea
Lusida, Maria Inge
Yudho Bintoro, Siprianus Ugroseno
Rahmawati, Lita Diah
I’tishom, Reny
Miftahussurur, Muhammad
Institución
Resumen
Colorectal cancer (CRC) is the fourth leading cause of cancer-related deaths worldwide. Various genetic and epigenetic changes in colonic epithelial cells, including DNA methylation, histone modifications, and noncoding RNAs, were involved in the initiation and progression of CRC. Moreover, epigenetic changes played an important role in CRC drug resistance. The dynamic and reversibility of epigenetic changes provide new possible therapeutic targets for colorectal cancer.