Articulo
TIP: protein backtranslation aided by genetic algorithms
Fecha
2004Registro en:
15000001
WOS:000223827000021
no scielo
eid=2-s2.0-4544291415
Institución
Resumen
Several applications require the backtranslation of a protein sequence into a nucleic acid sequence. The degeneracy of the genetic code makes this process ambiguous; moreover, not every translation is equally viable. The usual answer is to mimic the codon usage of the target species; however, this does not capture all the relevant features of the 'genomic styles' from different taxa. The program TIP ' Traducción Inversa de Proteínas') applies genetic algorithms to improve the backtranslation, by minimizing the difference of some coding statistics with respect to their average value in the target.