Impairment of angiogenic sphingosine kinase-1/sphingosine-1-phosphate receptors pathway in preeclampsia

Abstract

Preeclampsia (PE), is a serious pregnancy disorder characterized in the early gestation by shallow trophoblast invasion, impaired placental neo-angiogenesis, placental hypoxia and ischemia, which leads to maternal and fetal morbidity and mortality. Here