Artículo de publicación ISIThis study compared the effects of two velocity loss thresholds during a power-oriented resistance training program on the mechanical capacities of lower-body muscles. Twenty men were counterbalanced in two groups (VL10 and VL20) based on their maximum power capacity. Both groups used the same exercises, relative intensity and repetition volume, only differing in the velocity loss threshold of each set (VL10: 10% vs. VL20: 20%). Pre- and post-training assessments included an incremental loading test and a 15-m linear sprint to assess the force- and load-velocity relationships and athletic performance variables, respectively. No significant between-group differences (P > 0.05) were observed for the force-velocity relationship parameters (ES range = 0.15–0.42), the MPV attained against different external loads (ES range = 0.02–0.18) or the 15-m sprint time (ES = 0.09). A high between-participants variability was reported for the number of repetitions completed in each training set (CV = 30.3% for VL10 and 29.4% for VL20). These results suggest that both velocity loss thresholds induce similar changes on the lower-body function. The high and variable number of repetitions completed may compromise the velocity-based approach for prescribing and monitoring the repetition volume during a power-oriented resistance training program conducted with the countermovement jump exercise