info:eu-repo/semantics/article
Iron and Copper Toxicity in Rat Liver: A Kinetic and Holistic Overview
Fecha
2017-12Registro en:
Musacco Sebio, Rosario Natalia; Saporito Magriñá, Christian Martín; Acosta, Juan Manuel; Boveris, Alberto Antonio; Repetto, Marisa Gabriela; Iron and Copper Toxicity in Rat Liver: A Kinetic and Holistic Overview; Openventio Publishers; Liver Research; 2; 1; 12-2017; 9-13
2379-4038
CONICET Digital
CONICET
Autor
Musacco Sebio, Rosario Natalia
Saporito Magriñá, Christian Martín
Acosta, Juan Manuel
Boveris, Alberto Antonio
Repetto, Marisa Gabriela
Resumen
Iron (Fe) and copper (Cu) overloads in rats showed a dose and time dependent metal accumulationin liver with its associated toxicity. The increased contents of the transition metals markedly enhanced the endogenous free-radical mediated processes of phospholipid peroxidation. Invivo liver chemiluminescence showed an increased production of 1 O2, and a consumption ofreduced glutathione (GSH), the main intracellular antioxidant. Results fit with a Haber-Weiss type molecular mechanism in which Fe or Cu and endogenously produced O2- and H2O2, yield HO radical that initiates free-radical mediated phospholipid peroxidation and protein oxidation.