| dc.creator | Musacco Sebio, Rosario Natalia | |
| dc.creator | Saporito Magriñá, Christian Martín | |
| dc.creator | Acosta, Juan Manuel | |
| dc.creator | Boveris, Alberto Antonio | |
| dc.creator | Repetto, Marisa Gabriela | |
| dc.date.accessioned | 2018-12-19T15:01:02Z | |
| dc.date.accessioned | 2022-10-15T14:42:22Z | |
| dc.date.available | 2018-12-19T15:01:02Z | |
| dc.date.available | 2022-10-15T14:42:22Z | |
| dc.date.created | 2018-12-19T15:01:02Z | |
| dc.date.issued | 2017-12 | |
| dc.identifier | Musacco Sebio, Rosario Natalia; Saporito Magriñá, Christian Martín; Acosta, Juan Manuel; Boveris, Alberto Antonio; Repetto, Marisa Gabriela; Iron and Copper Toxicity in Rat Liver: A Kinetic and Holistic Overview; Openventio Publishers; Liver Research; 2; 1; 12-2017; 9-13 | |
| dc.identifier | 2379-4038 | |
| dc.identifier | http://hdl.handle.net/11336/66739 | |
| dc.identifier | CONICET Digital | |
| dc.identifier | CONICET | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/4398133 | |
| dc.description.abstract | Iron (Fe) and copper (Cu) overloads in rats showed a dose and time dependent metal accumulationin liver with its associated toxicity. The increased contents of the transition metals markedly enhanced the endogenous free-radical mediated processes of phospholipid peroxidation. Invivo liver chemiluminescence showed an increased production of 1 O2, and a consumption ofreduced glutathione (GSH), the main intracellular antioxidant. Results fit with a Haber-Weiss type molecular mechanism in which Fe or Cu and endogenously produced O2- and H2O2, yield HO radical that initiates free-radical mediated phospholipid peroxidation and protein oxidation. | |
| dc.language | eng | |
| dc.publisher | Openventio Publishers | |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.17140/LROJ-2-110 | |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://openventio.org/wp-content/uploads/Iron-and-Copper-Toxicity-in-Rat-Liver-A-Kinetic-and-Holistic-Overview-LROJ-2-110.pdf | |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.subject | IRON | |
| dc.subject | COPPER | |
| dc.subject | TOXICITY | |
| dc.subject | LIVER | |
| dc.title | Iron and Copper Toxicity in Rat Liver: A Kinetic and Holistic Overview | |
| dc.type | info:eu-repo/semantics/article | |
| dc.type | info:ar-repo/semantics/artículo | |
| dc.type | info:eu-repo/semantics/publishedVersion | |
