info:eu-repo/semantics/article
Tianeptine influence on plasmatic catecholamine levels and anxiety index in rats under variable chronic stress after early maternal separation
Fecha
2009-12Registro en:
Trujillo, Verónica; Masseroni, Maria Luján; Levin, Gloria Mabel; Suárez Marta Magdalena; Tianeptine influence on plasmatic catecholamine levels and anxiety index in rats under variable chronic stress after early maternal separation; Taylor & Francis Ltd; The International Journal Of Neuroscience.; 119; 8; 12-2009; 1210-1227
0020-7454
1543-5245
CONICET Digital
CONICET
Autor
Trujillo, Verónica
Masseroni, Maria Luján
Levin, Gloria Mabel
Suárez Marta Magdalena
Resumen
The aim of this work was to determine the effect of chronic treatment with 5 mg/Kg of tianeptine in male adult Wistar rats separated from the mother as neonates and submitted to variable chronic stress, plasma catecholamines, and anxiety. The plus maze test was performed in order to calculate the anxiety index and catecholamine levels were determined by high-pressure liquid chromatography. Both stress and maternal-separation elevated catecholamine levels without affecting anxiety. In the maternally separated stress group, tianeptine decreased epinephrine. Anxiety was reduced in the maternally separated unstressed tianeptine group. Also, all groups showed a tendency to lower anxiety index.