info:eu-repo/semantics/article
Nonalcoholic steatohepatitis is associated with a state of betaine-insufficiency
Fecha
2017-04Registro en:
Sookoian, Silvia Cristina; Puri, Puneet; Castaño, Gustavo Osvaldo; Scian, Romina; Mirshahi, Faridodin; et al.; Nonalcoholic steatohepatitis is associated with a state of betaine-insufficiency; Wiley Blackwell Publishing, Inc; Liver International; 37; 4; 4-2017; 611-619
1478-3223
CONICET Digital
CONICET
Autor
Sookoian, Silvia Cristina
Puri, Puneet
Castaño, Gustavo Osvaldo
Scian, Romina
Mirshahi, Faridodin
Sanyal, Arun J.
Pirola, Carlos José
Resumen
Background and Aims: Nonalcoholic fatty liver disease (NAFLD) develops from a complex process, which includes changes in the liver methylome. Betaine plays a pivotal role in the regulation of methylogenesis. We performed a two-stage case–control study, which included patients with biopsy-proven NAFLD to explore circulating levels of betaine and its association with the histological spectrum. We also explored the association between a missense rs1805074, p.Ser646Pro variant in DMGDH (dimethylglycine dehydrogenase mitochondrial) and NAFLD severity (n=390). Results: In the discovery phase (n=48), betaine levels were associated with the disease severity (P=.0030), including liver inflammation (Spearman R:−0.51, P=.001), ballooning degeneration (R: −0.50, P=.01) and fibrosis (R: −0.54, P=.0008). Betaine levels were significantly decreased in nonalcoholic steatohepatitis (NASH) in comparison with nonalcoholic fatty liver (NAFL). Further replication (n=51) showed that betaine levels were associated with advanced NAFLD (P=.0085), and patients with NASH had a 1.26-fold decrease in betaine levels compared with those with NAFL. The rs1805074 was significantly associated with the disease severity (P=.011). Conclusion: NAFLD severity is associated with a state of betaine-insufficiency.