dc.creator | Sookoian, Silvia Cristina | |
dc.creator | Puri, Puneet | |
dc.creator | Castaño, Gustavo Osvaldo | |
dc.creator | Scian, Romina | |
dc.creator | Mirshahi, Faridodin | |
dc.creator | Sanyal, Arun J. | |
dc.creator | Pirola, Carlos José | |
dc.date.accessioned | 2018-11-06T18:20:21Z | |
dc.date.accessioned | 2022-10-15T08:08:48Z | |
dc.date.available | 2018-11-06T18:20:21Z | |
dc.date.available | 2022-10-15T08:08:48Z | |
dc.date.created | 2018-11-06T18:20:21Z | |
dc.date.issued | 2017-04 | |
dc.identifier | Sookoian, Silvia Cristina; Puri, Puneet; Castaño, Gustavo Osvaldo; Scian, Romina; Mirshahi, Faridodin; et al.; Nonalcoholic steatohepatitis is associated with a state of betaine-insufficiency; Wiley Blackwell Publishing, Inc; Liver International; 37; 4; 4-2017; 611-619 | |
dc.identifier | 1478-3223 | |
dc.identifier | http://hdl.handle.net/11336/63788 | |
dc.identifier | CONICET Digital | |
dc.identifier | CONICET | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/4363597 | |
dc.description.abstract | Background and Aims: Nonalcoholic fatty liver disease (NAFLD) develops from a complex process, which includes changes in the liver methylome. Betaine plays a pivotal role in the regulation of methylogenesis. We performed a two-stage case–control study, which included patients with biopsy-proven NAFLD to explore circulating levels of betaine and its association with the histological spectrum. We also explored the association between a missense rs1805074, p.Ser646Pro variant in DMGDH (dimethylglycine dehydrogenase mitochondrial) and NAFLD severity (n=390). Results: In the discovery phase (n=48), betaine levels were associated with the disease severity (P=.0030), including liver inflammation (Spearman R:−0.51, P=.001), ballooning degeneration (R: −0.50, P=.01) and fibrosis (R: −0.54, P=.0008). Betaine levels were significantly decreased in nonalcoholic steatohepatitis (NASH) in comparison with nonalcoholic fatty liver (NAFL). Further replication (n=51) showed that betaine levels were associated with advanced NAFLD (P=.0085), and patients with NASH had a 1.26-fold decrease in betaine levels compared with those with NAFL. The rs1805074 was significantly associated with the disease severity (P=.011). Conclusion: NAFLD severity is associated with a state of betaine-insufficiency. | |
dc.language | eng | |
dc.publisher | Wiley Blackwell Publishing, Inc | |
dc.relation | info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1111/liv.13249 | |
dc.relation | info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/liv.13249 | |
dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | |
dc.rights | info:eu-repo/semantics/restrictedAccess | |
dc.subject | Betaine | |
dc.subject | Biomarkers | |
dc.subject | Dimethylglycine Dehydrogenase Mitochondrial | |
dc.subject | Dna Methylation | |
dc.subject | Epigenetics | |
dc.subject | Fibrosis | |
dc.subject | Genetics | |
dc.subject | Inflammation | |
dc.subject | Metabolomics | |
dc.subject | Nonalcoholic Fatty Liver Disease | |
dc.subject | Nonalcoholic Steatohepatitis | |
dc.title | Nonalcoholic steatohepatitis is associated with a state of betaine-insufficiency | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:ar-repo/semantics/artículo | |
dc.type | info:eu-repo/semantics/publishedVersion | |