info:eu-repo/semantics/article
Utilizing semantic intrusions to identify amyloid positivity in mild cognitive impairment
Fecha
2018-09Registro en:
Loewenstein, David A.; Curiel, Rosie E.; DeKosky, Steven; Bauer, Russell M.; Rosselli, Monica; et al.; Utilizing semantic intrusions to identify amyloid positivity in mild cognitive impairment; Lippincott Williams; Neurology; 91; 10; 9-2018; E976-E984
0028-3878
CONICET Digital
CONICET
Autor
Loewenstein, David A.
Curiel, Rosie E.
DeKosky, Steven
Bauer, Russell M.
Rosselli, Monica
Guinjoan, Salvador Martín
Adjouadi, Malek
Peñate, Ailyn
Barker, William W.
Goenaga, Sindy
Golde, Todd
Greig Custo, Maria T.
Hanson, Kevin S.
Li, Chunfei
Lizarraga, Gabriel
Marsiske, Michael
Duara, Ranjan
Resumen
Objective Semantic intrusion (SI) errors may highlight specific breakdowns in memory associated with preclinical Alzheimer disease (AD); however, there have been no investigations to determine whether SI errors occur with greater frequency in persons with amnestic mild cognitive impairment (aMCI) confirmed as amyloid positive (Amy+) vs those who have clinical symptoms of aMCI-AD with negative amyloid scans (suspected non-AD pathology [SNAP]) or persons who are diagnosed with other brain disorders affecting cognition. Methods Eighty-eight participants with aMCI underwent brain amyloid PET and MRI scans and were classified as early AD (Amy+), SNAP (Amy−), or other neurological/psychiatric diagnosis (Amy−). We focused on SI on the Loewenstein-Acevedo Scales for Semantic Interference and Learning (LASSI-L) targeting proactive semantic interference (PSI; old semantic learning interferes with new semantic learning), failure to recover from PSI after an additional learning trial (frPSI), and retroactive semantic interference (new semantic learning interferes with memory for old semantic learning). Results SIs on measures of PSI and frPSI distinguished between Amy+ AD and SNAP and other non-AD cases. PSI and frPSI intrusions evidenced moderately high associations with reduced volumes in the entorhinal cortex, superior temporal regions, and supramarginal gyrus. No such associations were observed in cases with SNAP. Conclusions SIs on the LASSI-L related to PSI and frPSI uniquely differentiated Amy+ and Amy− participants with aMCI and likely reflect deficits with inhibition and source memory in preclinical AD not captured by traditional cognitive measures. This may represent a specific, noninvasive test successful at distinguishing cases with true AD from those with SNAP.