HASTY modulates miRNA biogenesis by linking pri-miRNA transcription and processing

dc.creatorCambiagno, Damián Alejandro
dc.creatorGiudicatti, Axel Joel
dc.creatorArce, Agustín Lucas
dc.creatorGagliardi, Delfina
dc.creatorLi, Lei
dc.creatorYuan, Wei
dc.creatorLundberg, Derek S.
dc.creatorWeigel, Detlef
dc.creatorManavella, Pablo Andrés
dc.date.accessioned2021-10-28T13:57:30Z
dc.date.accessioned2022-10-15T03:23:58Z
dc.date.available2021-10-28T13:57:30Z
dc.date.available2022-10-15T03:23:58Z
dc.date.created2021-10-28T13:57:30Z
dc.date.issued2021-03
dc.identifierCambiagno, Damián Alejandro; Giudicatti, Axel Joel; Arce, Agustín Lucas; Gagliardi, Delfina; Li, Lei; et al.; HASTY modulates miRNA biogenesis by linking pri-miRNA transcription and processing; Oxford University Press; Molecular Plant; 14; 3; 3-2021; 426-439
dc.identifier1674-2052
dc.identifierhttp://hdl.handle.net/11336/145316
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4339747
dc.description.abstractHASTY, the plant ortholog of human exportin 5, was proposed to export miRNAs from the nucleus to the cytoplasm, whereas this has long been disputed. This study shows that HASTY, rather than acting as a miRNA cargo protein, promotes miRNA biogenesis by stabilizing a complex between DCL1 and Mediator at MIRNA loci, thereby acting as a linker between pri-miRNA transcription and processing.
dc.languageeng
dc.publisherOxford University Press
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S1674205220304500
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.molp.2020.12.019
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectGENE SILENCING
dc.subjectHASTY
dc.subjectMICRORNA
dc.subjectMIRNA BIOGENESIS
dc.subjectMIRNA NUCLEAR EXPORT
dc.titleHASTY modulates miRNA biogenesis by linking pri-miRNA transcription and processing
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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