info:eu-repo/semantics/article
1,3-dihydroxy-5-(tridec-4′,7′-dienyl)benzene: A new cytotoxic compound from Lithraea molleoides
Fecha
2005-12Registro en:
López, Paula Gladys; Ruffa, M.J.; Cavallaro, Lucia Vicenta; Campos, Rodolfo Hector; Martino, Virginia Susana; et al.; 1,3-dihydroxy-5-(tridec-4′,7′-dienyl)benzene: A new cytotoxic compound from Lithraea molleoides; Elsevier Gmbh; Phytomedicine; 12; 1-2; 12-2005; 108-111
0944-7113
CONICET Digital
CONICET
Autor
López, Paula Gladys
Ruffa, M.J.
Cavallaro, Lucia Vicenta
Campos, Rodolfo Hector
Martino, Virginia Susana
Ferraro, G.
Resumen
A dichloromethane extract from the leaves of Lithraea molleoides (Anacardiaceae), an argentine medicinal plant, showed cytotoxicity on human hepatocellular carcinoma cell line. Bioassay guided fractionation of this extract led to the isolation of a new active 5-alkyl resorcinol: 1,3-dihydroxy-5-(tridec-4′,7′-dienyl)benzene. Chemical structure was established based on spectroscopic data (UV, IR, MS, 1H-NMR, 13C-NMR, COSY). This compound presented cytotoxic activity on 3 human tumoral cell lines: hepatocellular carcinoma cell line-Hep G2 (IC 50±SD of 68±2 μM), mucoepidermoid pulmonary carcinoma cell line-H292 (IC50±SD of 63±5 μM) and mammary gland adenocarcinoma cell line -MCF7 (IC50±SD of 147±5).