1,3-dihydroxy-5-(tridec-4′,7′-dienyl)benzene: A new cytotoxic compound from Lithraea molleoides

dc.creatorLópez, Paula Gladys
dc.creatorRuffa, M.J.
dc.creatorCavallaro, Lucia Vicenta
dc.creatorCampos, Rodolfo Hector
dc.creatorMartino, Virginia Susana
dc.creatorFerraro, G.
dc.date.accessioned2021-08-06T12:09:55Z
dc.date.accessioned2022-10-15T02:43:20Z
dc.date.available2021-08-06T12:09:55Z
dc.date.available2022-10-15T02:43:20Z
dc.date.created2021-08-06T12:09:55Z
dc.date.issued2005-12
dc.identifierLópez, Paula Gladys; Ruffa, M.J.; Cavallaro, Lucia Vicenta; Campos, Rodolfo Hector; Martino, Virginia Susana; et al.; 1,3-dihydroxy-5-(tridec-4′,7′-dienyl)benzene: A new cytotoxic compound from Lithraea molleoides; Elsevier Gmbh; Phytomedicine; 12; 1-2; 12-2005; 108-111
dc.identifier0944-7113
dc.identifierhttp://hdl.handle.net/11336/137937
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4336427
dc.description.abstractA dichloromethane extract from the leaves of Lithraea molleoides (Anacardiaceae), an argentine medicinal plant, showed cytotoxicity on human hepatocellular carcinoma cell line. Bioassay guided fractionation of this extract led to the isolation of a new active 5-alkyl resorcinol: 1,3-dihydroxy-5-(tridec-4′,7′-dienyl)benzene. Chemical structure was established based on spectroscopic data (UV, IR, MS, 1H-NMR, 13C-NMR, COSY). This compound presented cytotoxic activity on 3 human tumoral cell lines: hepatocellular carcinoma cell line-Hep G2 (IC 50±SD of 68±2 μM), mucoepidermoid pulmonary carcinoma cell line-H292 (IC50±SD of 63±5 μM) and mammary gland adenocarcinoma cell line -MCF7 (IC50±SD of 147±5).
dc.languageeng
dc.publisherElsevier Gmbh
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0944711304000960
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.phymed.2003.07.013
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subject1,3-DIHYDROXY-5-(TRIDEC-4′,7′-DIENYL)BENZENE
dc.subject5-ALKYLRESORCINOL
dc.subjectCYTOTOXIC ACTIVITY
dc.subjectLITHRAEA MOLLEOIDES
dc.title1,3-dihydroxy-5-(tridec-4′,7′-dienyl)benzene: A new cytotoxic compound from Lithraea molleoides
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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