info:eu-repo/semantics/article
Genomic and phylogenetic analysis of hepatitis C virus isolates from Argentine patients: A six-year retrospective study
Fecha
2000-12Registro en:
Quarleri, Jorge Fabian; Robertson, B.H.; Mathet, Veronica Lidia; Feld, Mariana; Espínola, Luis Alberto; et al.; Genomic and phylogenetic analysis of hepatitis C virus isolates from Argentine patients: A six-year retrospective study; American Society for Microbiology; Journal of Clinical Microbiology; 38; 12; 12-2000; 4560-4568
0095-1137
CONICET Digital
CONICET
Autor
Quarleri, Jorge Fabian
Robertson, B.H.
Mathet, Veronica Lidia
Feld, Mariana
Espínola, Luis Alberto
Requeijo, M.P.
Mandó, Oscar Gaspar
Carballal, Guadalupe
Oubiña, Jose Raul
Resumen
Typing of hepatitis C virus (HCV) isolates from Argentine patients was performed by using different methodologies in a population of 243 patients. HCV subtype was assigned based upon restriction fragment length polymorphism (RFLP). HCV RNA genomes obtained from serum samples were classified as belonging to clade 1 (53.5%), 2 (23.0%), or 3 (8.6%); 14.8% of samples showed HCV mixed infections, more frequently implying different subtypes within the same clade. In addition to RFLP typing, phylogenetic relatedness among sequences from both 5′ untranslated region (n = 50) and nonstructural 5B coding region (n = 15) was established.