Increased frequencies of activating natural killer receptors are associated with liver injury in individuals who do not eliminate hepatitis C virus

dc.creatorPaladino, Natalia
dc.creatorFlores, Ana Claudia
dc.creatorMarcos, Cintia Yanina
dc.creatorFainboim, Hugo
dc.creatorTheiler, Gerardo Raul
dc.creatorArruvito, Maria Lourdes
dc.creatorWilliams, F.
dc.creatorMiddleton, D.
dc.creatorFainboim, Leonardo
dc.date.accessioned2020-10-15T14:42:20Z
dc.date.accessioned2022-10-15T00:04:16Z
dc.date.available2020-10-15T14:42:20Z
dc.date.available2022-10-15T00:04:16Z
dc.date.created2020-10-15T14:42:20Z
dc.date.issued2007-12
dc.identifierPaladino, Natalia; Flores, Ana Claudia; Marcos, Cintia Yanina; Fainboim, Hugo; Theiler, Gerardo Raul; et al.; Increased frequencies of activating natural killer receptors are associated with liver injury in individuals who do not eliminate hepatitis C virus; Wiley Blackwell Publishing, Inc; Tissue Antigens; 69; SUPPL. 1; 12-2007; 109-111
dc.identifier0001-2815
dc.identifierhttp://hdl.handle.net/11336/115967
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4322636
dc.description.abstractThis study was designed to investigate the role of KIR genes in the outcome of HCV infection. In patients who cleared the virus (HCV RNA-) we found a decrease of 2DL2 (p=0.04), and 2DS2 (p=0.014) accompanied by an increase of 2DS5 (p=0.04). Those RNA+ patients with elevated levels of hepatic transaminases (HCV RNA+ elevatedALT) showed an increased frequency of 2DS3 (p=0.018). Additionally, in cirrhotic patients we found an increased frequency of individuals having two copies of 3DS1 and HLA-Bw4 (p=0.016). We conclude that higher NK cytotoxicity might be associated with a worse progression of the HCV infection.
dc.languageeng
dc.publisherWiley Blackwell Publishing, Inc
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1399-0039.2006.762_7.x
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/j.1399-0039.2006.762_7.x
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectnatural killer cells
dc.subjectHLA
dc.subjectcirrhosis
dc.subjecthepatitis C virus
dc.titleIncreased frequencies of activating natural killer receptors are associated with liver injury in individuals who do not eliminate hepatitis C virus
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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