Osmotic stress induces apoptosis in extravillous trophoblast cells. Role of TRPV-1

dc.creatorReppetti, Julieta
dc.creatorEtcheverry, Tomás
dc.creatorSierra, Matías N.
dc.creatorDamiano, Alicia Ermelinda
dc.creatorFarina, Mariana
dc.creatorMartinez, Nora Alicia
dc.date.accessioned2020-12-17T13:49:06Z
dc.date.accessioned2022-10-14T21:32:50Z
dc.date.available2020-12-17T13:49:06Z
dc.date.available2022-10-14T21:32:50Z
dc.date.created2020-12-17T13:49:06Z
dc.date.issued2019-06
dc.identifierReppetti, Julieta; Etcheverry, Tomás; Sierra, Matías N.; Damiano, Alicia Ermelinda; Farina, Mariana; et al.; Osmotic stress induces apoptosis in extravillous trophoblast cells. Role of TRPV-1; Academic Press Inc Elsevier Science; Biochemical and Biophysical Research Communications; 514; 1; 6-2019; 58-63
dc.identifier0006-291X
dc.identifierhttp://hdl.handle.net/11336/120728
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4309072
dc.description.abstractIn different tissues hyperosmolarity induces cell differentiation. Nevertheless an exacerbated hyperosmolar stress alters the normal cellular development. The transient receptor potential vanilloid 1 (TRPV-1) is a non-selective cation channel that is activated by hyperosmolarity and participates in many cellular processes. TPRV-1 is expressed in human placenta at term. Here, we evaluated the expression of TRPV-1 in first trimester extravillous trophoblast cells and its participation in the survival of these cells exposed to hyperosmolar stress. Our results showed that hyperosmolar stress up-regulates the expression of TRPV-1 and induces the apoptosis in Swan 71 cells. In addition, the inhibition of TRPV-1 abrogates the apoptotic events.
dc.languageeng
dc.publisherAcademic Press Inc Elsevier Science
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0006291X19307338
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.bbrc.2019.04.091
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectAPOPTOSIS
dc.subjectEVT
dc.subjectHYPEROSMOLARITY
dc.subjectTRPV-1
dc.titleOsmotic stress induces apoptosis in extravillous trophoblast cells. Role of TRPV-1
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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