SUMMARY The epidemiological transition for the State of Mexico has been changing over time, likewise its territorial behavior is not known. The objective of this work is to analyze the territorial distribution of the spatio-temporal behavior of the epidemiological transition in the State of Mexico. As a theoretical basis, the classical theory of epidemiological transition is considered, which consists of the changes that occur between health patterns and their relationship with social, economic and demographic determinants. Keywords: Transition; epidemiology; GBD list; bivariate; demography.El presente trabajo de investigación tiene como objetivo analizar la distribución territorial del comportamiento espacio-temporal de la transición epidemiológica en el Estado de México, de acuerdo al contexto territorial.