Dissertação
Fatores neurotróficos na epilepsia de lobo temporal
Fecha
2019-02-20Autor
Erika Machado Viana
Institución
Resumen
Background: Epilepsy is one of the most common neurological diseases affecting 0.5 to 2%
of the population worldwide. Temporal lobe epilepsy (TLE) is the most common epileptic
syndrome in adults and is often refractory to antiepileptic drugs. Its etiopathogenesis is complex
and not fully understood. The neurotrophic factors brain derived neurotrophic factor (BDNF)
and glia derived neurotrophic factor (GDNF) may play a role in the pathophysiology of
epilepsy. This study aimed to investigate sociodemographic and clinical characteristics of
patients with (TLE) and their association with plasma levels of BDNF and GDNF.
Methods: Sixty-six patients with TLE and 52 healthy controls were enrolled in the study.
Patients underwent a systematic clinical and psychiatric assessment, and plasma levels of
BDNF and GDNF were measured in the interictal period. The patients were subdivided into
subgroups according to clinical characteristics such as seizure types and frequency, duration of
epilepsy, current antiepileptic treatment, results of neuroimaging studies and presence of
cormorbid depressive symptoms.
Results: There was no difference between plasmatic BDNF and GDNF in patients with TLE
compared to controls. Reduced plasmatic levels of BDNF were observed in patients with longer
history of TLE, but not in association to other parameters. Plasma levels of BDNF and GDNF
were not different in patients or controls with depression.
Conclusion: Low plasma levels of BDNF seem to be associated with long-term ELT.