Artículos de revistas
Synthesis of tricyclic analogs of stephaoxocanidine and their evaluation as acetylcholinesterase inhibitors
Registro en:
Bioorganic & Medicinal Chemistry Letters 15 (11): 2711-2715
Autor
Bianchi, D.A.
Schmeda-Hirschmann, G.
Theoduloz, C.
Bracca, A.B.J.
Kaufman, T.S.
Institución
Resumen
Schmeda-Hirschmann, G. Laboratorio de Quımica de Productos Naturales, Instituto de Quımica de Recursos Naturales, Universidad de Talca, Casilla 747, Talca, Chile. Theoduloz C. Facultad de Ciencias de la Salud, Laboratorio de Cultivo Celular, Universidad de Talca, Casilla 747, Talca, Chile The synthesis of simplified analogs of the novel isoquinoline alkaloid stephaoxocanidine, carrying the oxazaphenalene ABC-ring system of the natural product, and their activity as inhibitors of the enzyme acetylcholinesterase, are reported. 5,6-Dimethoxy-7H-8-oxa-1-aza-phenalen-9-one (5) was as active as a Narcissus extract enriched in galantamine.