Synthesis of tricyclic analogs of stephaoxocanidine and their evaluation as acetylcholinesterase inhibitors

dc.creatorBianchi, D.A.
dc.creatorSchmeda-Hirschmann, G.
dc.creatorTheoduloz, C.
dc.creatorBracca, A.B.J.
dc.creatorKaufman, T.S.
dc.date2005-10-06T22:45:44Z
dc.date2005-10-06T22:45:44Z
dc.date2005-06-02
dc.date.accessioned2017-03-07T14:32:25Z
dc.date.available2017-03-07T14:32:25Z
dc.identifierBioorganic & Medicinal Chemistry Letters 15 (11): 2711-2715
dc.identifierhttp://dx.doi.org/10.1016/j.bmcl.2005.04.005
dc.identifierhttp://dspace.utalca.cl/handle/1950/1547
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/368858
dc.descriptionSchmeda-Hirschmann, G. Laboratorio de Quımica de Productos Naturales, Instituto de Quımica de Recursos Naturales, Universidad de Talca, Casilla 747, Talca, Chile.
dc.descriptionTheoduloz C. Facultad de Ciencias de la Salud, Laboratorio de Cultivo Celular, Universidad de Talca, Casilla 747, Talca, Chile
dc.descriptionThe synthesis of simplified analogs of the novel isoquinoline alkaloid stephaoxocanidine, carrying the oxazaphenalene ABC-ring system of the natural product, and their activity as inhibitors of the enzyme acetylcholinesterase, are reported. 5,6-Dimethoxy-7H-8-oxa-1-aza-phenalen-9-one (5) was as active as a Narcissus extract enriched in galantamine.
dc.description
dc.format4678 bytes
dc.formatimage/jpeg
dc.languageen
dc.publisherPergamon-Elsevier Science Ltd.
dc.subjectacetylcholinesterase inhibitors
dc.subjectoxazaphenalenes
dc.subjectstephaoxocanes
dc.subjectisoquinoline alkaloids
dc.titleSynthesis of tricyclic analogs of stephaoxocanidine and their evaluation as acetylcholinesterase inhibitors
dc.typeArtículos de revistas


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