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        Purinergic signaling in infectious diseases of the central nervous system

        Registro en:
        0889-1591
        https://doi.org/10.1016/j.bbi.2020.07.026
        http://hdl.handle.net/20.500.12010/11748
        https://doi.org/10.1016/j.bbi.2020.07.026
        http://repositorioslatinoamericanos.uchile.cl/handle/2250/3506754
        Autor
        Santos Alves, Vinícius
        Leite-Aguiar, Raíssa
        Pereira da Silva, Joyce
        Coutinho-Silva, Robson
        Baggio Savio, Luiz Eduardo
        Institución
        • Universidad Jorge Tadeo Lozano (Colombia)
        Resumen
        The incidence of infectious diseases affecting the central nervous system (CNS) has been increasing over the last several years. Among the reasons for the expansion of these diseases and the appearance of new neuropathogens are globalization, global warming, and the increased proximity between humans and wild animals due to human activities such as deforestation. Neurotropism affecting normal brain function is shared by organisms such as viruses, bacteria, fungi, and parasites. Neuroinfections caused by these agents activate immune responses, inducing neuroinflammation, excitotoxicity, and neurodegeneration. Purinergic signaling is an evolutionarily conserved signaling pathway associated with these neuropathologies. During neuroinfections, host cells release ATP as an extracellular danger signal with pro-inflammatory activities. ATP is metabolized to its derivatives by ectonucleotidases such as CD39 and CD73; ATP and its metabolites modulate neuronal and immune mechanisms through P1 and P2 purinergic receptors that are involved in pathophysiological mechanisms of neuroinfections. In this review we discuss the beneficial or deleterious effects of various components of the purinergic signaling pathway in infectious diseases that affect the CNS, including human immunodeficiency virus (HIV-1) infection, herpes simplex virus type 1 (HSV-1) infection, bacterial meningitis, sepsis, cryptococcosis, toxoplasmosis, and malaria. We also provide a description of this signaling pathway in emerging viral infections with neurological implications such as Zika and SARS-CoV-2.
        Materias
        Neuroinfections
        Neuroinflammation
        Cerebral toxoplasmosis
        Zika
        SARSCoV-2
        P2 receptor
        CD39
        CD73
        Adenosine

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        Red de Repositorios Latinoamericanos
        + de 8.000.000 publicaciones disponibles
        500 instituciones participantes
        Dirección de Servicios de Información y Bibliotecas (SISIB)
        Universidad de Chile
        Ingreso Administradores
        Colecciones destacadas
        • Tesis latinoamericanas
        • Tesis argentinas
        • Tesis chilenas
        • Tesis peruanas
        Nuevas incorporaciones
        • Argentina
        • Brasil
        • Colombia
        • México
        Dirección de Servicios de Información y Bibliotecas (SISIB)
        Universidad de Chile
        Red de Repositorios Latinoamericanos | 2006-2018