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CD73 restringe la adquisición de un fenotipo efector en linfocitos TCD8+.
(Universidad de Chile., 2021)
La adenosina es un nucleósido que inhibe la activación y función de los linfocitos T CD8+. Se ha descrito que la señalización de adenosina por medio del receptor A2A, regula negativamente las señales derivadas del ...
“El papel de CD73 en la regulación de la cadena alfa del receptor de interleuquina 7 (CD127) en Timocitos”
(Universidad de Chile, 2022)
Los linfocitos T son células especializadas del sistema inmune que sufren procesos de diferenciación y selección en el timo antes de salir a la circulación. En este proceso de diferenciación, los precursores de las células ...
Ecto-5′-nucleotidase (CD73) regulates the survival of CD8+ T cells
(Frontiers Media, 2021)
Ecto-5 '-nucleotidase (CD73) is an enzyme present on the surface of tumor cells whose primary described function is the production of extracellular adenosine. Due to the immunosuppressive properties of adenosine, CD73 is ...
CD73 presente en linfocitos T CD8+ favorece su proliferación homeostática e inhibe su capacidad efectora
(Universidad de Chile, 2020)
La respuesta inmune mediada por los linfocitos T (LT) CD8+ requiere que estas
células sean capaces de diferenciarse hacia células efectoras citotóxicas y de memoria
que puedan producir una respuesta cada vez más efectiva. ...
CD73 ectonucleotidase restrains CD8+T cell metabolic fitness and anti-tumoral activity
(Frontiers Media, 2021)
CD39 and CD73 are ectoenzymes that dephosphorylate ATP into its metabolites; ADP, AMP, and adenosine, and thus are considered instrumental in the development of immunosuppressive microenvironments. We have previously shown ...
CD73 Ectonucleotidase Restrains CD8+ T Cell Metabolic Fitness and Anti-tumoral Activity
(2021-02-18)
CD39 and CD73 are ectoenzymes that dephosphorylate ATP into its metabolites; ADP, AMP, and adenosine, and thus are considered instrumental in the development of immunosuppressive microenvironments. We have previously shown ...
Ecto-5′-Nucleotidase (CD73) Regulates the Survival of CD8+ T Cells
(2021-04-13)
Ecto-5′-nucleotidase (CD73) is an enzyme present on the surface of tumor cells whose primary described function is the production of extracellular adenosine. Due to the immunosuppressive properties of adenosine, CD73 is ...
In vivo analysis of the presence of heme oxygenase-1, transcription factor Jun-D and CD90+/CD73+/CD105+/CD45- cells in the pulp of bleached teeth
(2019-01-01)
Aim: To investigate hydrogen peroxide (H2O2)-induced responsiveness in pulp cells using heme oxygenase-1 (HO-1) immunolabelling, Jun-D immunolabelling to study the effects of H2O2 on odontoblastic differentiation and ...
CD73 Ectonucleotidase Restrains CD8+T Cell Metabolic Fitness and Anti-tumoral Activity 1 of 1 CD73 Ectonucleotidase Restrains CD8+T Cell Metabolic Fitness and Anti-tumoral Activity
(FRONTIERS MEDIA SA, 2021-02-18)
CD39 and CD73 are ectoenzymes that dephosphorylate ATP into its metabolites; ADP, AMP, and adenosine, and thus are considered instrumental in the development of immunosuppressive microenvironments. We have previously shown ...