Efecto de Lentinula edodes a dosis homeopáticas, en un modelo murino de melanoma

Abstract

The increasing global statistics of the morbi-mortality caused by the skin cancer makes it a serious health problem. In Mexico, the cases of malignant melanoma have increased up to a 500% in the last years and it is expected these tendencies continue until 2020. Until this moment the conventional therapies do not offer a better forecast to the patients who have it, therefore it is important to look for alternative therapies. The following proprieties; antivirals, antibacterials, antiinflammatory, antiparasit, antifungal are attributed to the fungus Lentinula edodes, specially the antitumor due to its actives, some of them are the lentinian, inductor of interferon, ergosterol , among others; however, there are no reports of its effects in homeopathic doses, therefore in this work it was realized the induction of melanoma in mice C57BL/6 by the intradermic inoculation of the cellular line B16- F0, offering them as a treatment the L. edodes in homeopathic doses 6CH and 12CH. As a result it was observed that the better antitumor effect it has the group treated with the L. edodes 12CH. This assertion was corroborated by a statistical analysis, by means of Student T test for independents samples. The statistically significant results were obtained by the group 12CH compared with the group L. edodes 6CH (P= 0.04376) and by the group L. edodes 12 CH compared with the group negative control (homeopathic alcohol) (P=0.00003). The antitumoral effect was double checked by a histopathological analysis, from biopsies taken in all groups, this fact proved that the tissues obtained from these murinus do not show any evidence of neoplastic cells.