dc.contributorM. en C. García Morales, Lorena
dc.contributorD. en C.Ramírez Moreno, María Esther
dc.creatorAguilar Cruz, Laura Lorena
dc.date.accessioned2013-05-28T19:50:53Z
dc.date.available2013-05-28T19:50:53Z
dc.date.created2013-05-28T19:50:53Z
dc.date.issued2010-08-25
dc.identifierhttp://www.repositoriodigital.ipn.mx/handle/123456789/16162
dc.description.abstractThe increasing global statistics of the morbi-mortality caused by the skin cancer makes it a serious health problem. In Mexico, the cases of malignant melanoma have increased up to a 500% in the last years and it is expected these tendencies continue until 2020. Until this moment the conventional therapies do not offer a better forecast to the patients who have it, therefore it is important to look for alternative therapies. The following proprieties; antivirals, antibacterials, antiinflammatory, antiparasit, antifungal are attributed to the fungus Lentinula edodes, specially the antitumor due to its actives, some of them are the lentinian, inductor of interferon, ergosterol , among others; however, there are no reports of its effects in homeopathic doses, therefore in this work it was realized the induction of melanoma in mice C57BL/6 by the intradermic inoculation of the cellular line B16- F0, offering them as a treatment the L. edodes in homeopathic doses 6CH and 12CH. As a result it was observed that the better antitumor effect it has the group treated with the L. edodes 12CH. This assertion was corroborated by a statistical analysis, by means of Student T test for independents samples. The statistically significant results were obtained by the group 12CH compared with the group L. edodes 6CH (P= 0.04376) and by the group L. edodes 12 CH compared with the group negative control (homeopathic alcohol) (P=0.00003). The antitumoral effect was double checked by a histopathological analysis, from biopsies taken in all groups, this fact proved that the tissues obtained from these murinus do not show any evidence of neoplastic cells.
dc.languagees
dc.subjectMelanoma
dc.subjectLentinula edodes
dc.subjectdosis homeopáticas
dc.titleEfecto de Lentinula edodes a dosis homeopáticas, en un modelo murino de melanoma
dc.typeThesis


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