dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2014-05-27T11:30:06Z
dc.date.available2014-05-27T11:30:06Z
dc.date.created2014-05-27T11:30:06Z
dc.date.issued2013-08-01
dc.identifierJournal of Oral Pathology and Medicine, v. 42, n. 7, p. 570-575, 2013.
dc.identifier0904-2512
dc.identifier1600-0714
dc.identifierhttp://hdl.handle.net/11449/76164
dc.identifier10.1111/jop.12029
dc.identifierWOS:000329226600010
dc.identifier2-s2.0-84880758657
dc.identifier6065636367717382
dc.identifier6543563161403421
dc.identifier0000-0002-4470-5171
dc.identifier0000-0002-2416-2173
dc.description.abstractBackground: The aim of this study was to evaluate the frequency of Candida species and presence of lesions in the oral cavity of patients with sickle cell anemia (SS). Methods: The study included 30 patients diagnosed with sickle cell anemia and taking hydroxyurea for at least 90 days (SS/HU+); and 39 patients with sickle cell anemia and without hydroxyurea therapy (SS/HU-). Two control groups were constituted by healthy individuals matched to the test groups in age, gender, and oral conditions (C/HU+ for SS/HU+ and C/HU- for SS/HU-). Oral clinical examination and anamnesis were performed. Yeasts were collected by oral rinses and identified by API system. Antifungal susceptibility evaluation was performed according to the CLSI methodology. Data obtained for microorganisms counts were compared by Student's t test (SS/HU+ vs. C/HU+ and SS/HU- vs. C/HU-) using MINITAB for Windows 1.4. Significance level was set at 5%. Results: No oral candidosis lesions were detected. Significant differences in yeasts counts were observed between SS/HU- group and the respective control, but there were no differences between SS/HU+ and C/HU+. Candida albicans was the most prevalent species in all groups. Candida famata was observed both in SS and control groups. Candida dubliniensis, Candida glabrata, Candida krusei, Candida tropicalis, Candida pelliculosa, and Candida parapsilosis were observed only in SS groups. Most strains were susceptible to all antifungal agents. Conclusion: Hydroxyurea therapy seems to decrease candidal counts and resistance rate in sickle cell anemia patients. However, further studies should be conducted in the future to confirm this finding. Hydroxyurea therapy in sickle cell anemia patients maintains fungal species balance in oral cavity. © 2013 John Wiley & Sons A/S.
dc.languageeng
dc.relationJournal of Oral Pathology and Medicine
dc.relation2.237
dc.relation0,791
dc.relation0,791
dc.rightsAcesso restrito
dc.sourceScopus
dc.subjectAntifungals
dc.subjectHydroxyurea
dc.subjectMicrobiology
dc.subjectOral cavity
dc.subjectSickle cell anemia
dc.subjecthydroxyurea
dc.subjectadult
dc.subjectanamnesis
dc.subjectantibiotic sensitivity
dc.subjectantifungal susceptibility
dc.subjectCandida
dc.subjectCandida albicans
dc.subjectCandida dubliniensis
dc.subjectCandida famata
dc.subjectCandida glabrata
dc.subjectCandida parapsilosis
dc.subjectCandida tropicalis
dc.subjectclinical article
dc.subjectclinical examination
dc.subjectcontrolled study
dc.subjectcross-sectional study
dc.subjectfemale
dc.subjectfungal colonization
dc.subjecthuman
dc.subjectmale
dc.subjectmouth lesion
dc.subjectPichia anomala
dc.subjectprevalence
dc.subjectpriority journal
dc.subjectsickle cell anemia
dc.titleHydroxyurea therapy in sickle cell anemia patients aids to maintain oral fungal colonization balance
dc.typeArtículos de revistas


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