Artículos de revistas
Celecoxib/PLGA suppresses angiogenesis and lung metastasis of murine experimental breast cancer Celecoxib/PLGA suprime angiogénesis y metástasis pulmonar de un cáncer mamario murino experimental
Fecha
2016Registro en:
International Journal of Morphology, Volumen 34, Issue 1, 2018, Pages 335-341
07179502
07179367
10.4067/S0717-95022016000100048
Autor
Roa, Ignacio
Cantín, Mario
Muñoz, Mariela
Rosas, Carlos
Lemus, David
Institución
Resumen
© 2016, Universidad de la Frontera. All rights reserved.Angiogenesis and metastasis are critical events on the tumor invasion process. Their close association is related as a good target in antitumor therapy. The aimwas to analyze lung metastasis pattern and angiogenesis following application of microencapsulated Celecoxib with poli(lactic-co-glycolic) acid in mice.An experimental tumor model was assessed, induced by TA3-MTX-R cells, in 18 mice, separated in 3 groups of 6 animals and treated with 2 intramuscular Celecoxib presentations (Group Control; Group Cx 1000 ppm and Group Cx 1000 ppm+PLGA). Mice were sacrificed and histologically processed to stain slides with H&E andArteta Trichromic. The study revealed that the lung showed a significant heterogeneity, and a perivascular metastasis pattern; moreover, Celecoxib associated to poli(lactic-co-glycolic) acid reduces tumor invasion and pulmonary angiogenesis. The results are similar to partial previous descriptions and are comparable