dc.creatorRoa, Ignacio
dc.creatorCantín, Mario
dc.creatorMuñoz, Mariela
dc.creatorRosas, Carlos
dc.creatorLemus, David
dc.date.accessioned2019-03-18T11:54:17Z
dc.date.available2019-03-18T11:54:17Z
dc.date.created2019-03-18T11:54:17Z
dc.date.issued2016
dc.identifierInternational Journal of Morphology, Volumen 34, Issue 1, 2018, Pages 335-341
dc.identifier07179502
dc.identifier07179367
dc.identifier10.4067/S0717-95022016000100048
dc.identifierhttps://repositorio.uchile.cl/handle/2250/166784
dc.description.abstract© 2016, Universidad de la Frontera. All rights reserved.Angiogenesis and metastasis are critical events on the tumor invasion process. Their close association is related as a good target in antitumor therapy. The aimwas to analyze lung metastasis pattern and angiogenesis following application of microencapsulated Celecoxib with poli(lactic-co-glycolic) acid in mice.An experimental tumor model was assessed, induced by TA3-MTX-R cells, in 18 mice, separated in 3 groups of 6 animals and treated with 2 intramuscular Celecoxib presentations (Group Control; Group Cx 1000 ppm and Group Cx 1000 ppm+PLGA). Mice were sacrificed and histologically processed to stain slides with H&E andArteta Trichromic. The study revealed that the lung showed a significant heterogeneity, and a perivascular metastasis pattern; moreover, Celecoxib associated to poli(lactic-co-glycolic) acid reduces tumor invasion and pulmonary angiogenesis. The results are similar to partial previous descriptions and are comparable
dc.languageen
dc.publisherUniversidad de la Frontera
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
dc.sourceInternational Journal of Morphology
dc.subjectAngiogenesis
dc.subjectCancer
dc.subjectCelecoxib
dc.subjectLung
dc.subjectMetastasis
dc.subjectPLGA
dc.titleCelecoxib/PLGA suppresses angiogenesis and lung metastasis of murine experimental breast cancer Celecoxib/PLGA suprime angiogénesis y metástasis pulmonar de un cáncer mamario murino experimental
dc.typeArtículos de revistas


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