dc.creator | Roa, Ignacio | |
dc.creator | Cantín, Mario | |
dc.creator | Muñoz, Mariela | |
dc.creator | Rosas, Carlos | |
dc.creator | Lemus, David | |
dc.date.accessioned | 2019-03-18T11:54:17Z | |
dc.date.available | 2019-03-18T11:54:17Z | |
dc.date.created | 2019-03-18T11:54:17Z | |
dc.date.issued | 2016 | |
dc.identifier | International Journal of Morphology, Volumen 34, Issue 1, 2018, Pages 335-341 | |
dc.identifier | 07179502 | |
dc.identifier | 07179367 | |
dc.identifier | 10.4067/S0717-95022016000100048 | |
dc.identifier | https://repositorio.uchile.cl/handle/2250/166784 | |
dc.description.abstract | © 2016, Universidad de la Frontera. All rights reserved.Angiogenesis and metastasis are critical events on the tumor invasion process. Their close association is related as a good target in antitumor therapy. The aimwas to analyze lung metastasis pattern and angiogenesis following application of microencapsulated Celecoxib with poli(lactic-co-glycolic) acid in mice.An experimental tumor model was assessed, induced by TA3-MTX-R cells, in 18 mice, separated in 3 groups of 6 animals and treated with 2 intramuscular Celecoxib presentations (Group Control; Group Cx 1000 ppm and Group Cx 1000 ppm+PLGA). Mice were sacrificed and histologically processed to stain slides with H&E andArteta Trichromic. The study revealed that the lung showed a significant heterogeneity, and a perivascular metastasis pattern; moreover, Celecoxib associated to poli(lactic-co-glycolic) acid reduces tumor invasion and pulmonary angiogenesis. The results are similar to partial previous descriptions and are comparable | |
dc.language | en | |
dc.publisher | Universidad de la Frontera | |
dc.rights | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
dc.source | International Journal of Morphology | |
dc.subject | Angiogenesis | |
dc.subject | Cancer | |
dc.subject | Celecoxib | |
dc.subject | Lung | |
dc.subject | Metastasis | |
dc.subject | PLGA | |
dc.title | Celecoxib/PLGA suppresses angiogenesis and lung metastasis of murine experimental breast cancer Celecoxib/PLGA suprime angiogénesis y metástasis pulmonar de un cáncer mamario murino experimental | |
dc.type | Artículos de revistas | |