Artículo de revista
Changes in ghrelin concentrations one year after resective and non-resective gastric bypass: Associations with weight loss and energy and macronutrient intakes
Fecha
2012Registro en:
Nutrition, Volumen 28, Issue 7-8, 2018, Pages 757-761
08999007
18731244
10.1016/j.nut.2011.11.004
Autor
Carrasco, Fernando
Arenas Rojas, Pamela
Csendes Juhasz, Attila
Codoceo, Juana
Inostroza, Jorge
Basfi-fer Obregón, Karen
Papapietro Vallejo, Karin
Watkins, Guillermo
Vargas Rojas, Jorge Antonio
Ruz, Manuel
Institución
Resumen
Objective: Ghrelin is a potent stimulator of appetite and synthesized in the stomach. Its role in weight loss after gastric bypass (GBP) is still controversial. The aim of this study was to evaluate the relation between weight loss and food intake and between weight loss and changes in serum ghrelin concentrations 1 y after GBP with resection of the bypassed stomach (R-GBP) and without resection (NR-GBP). Methods: Of 50 women (37.6 ± 10.2 y old, body mass index 43.8 ± 4.8 kg/m 2) with GBP, 26 had R-GBP and 24 had NR-GBP. Body weight, body composition (dual energy x-ray absorptiometry), food intake, and serum ghrelin at baseline and 12 mo after GBP were measured. Results: The percentage of excess weight loss was 68.9 ± 12.8% at 12 mo after GBP. At 12 mo, the decrease of serum ghrelin was greater in the R-GBP group (-25.3 ± 22.5%) compared with the NR-GBP group (+11.2 ± 50.9%, P < 0.005). After adjustment by the baseline excess of body weight, there was a greater percentage of excess wei