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Analysis of Brain Nuclei Accessible to Ghrelin Present in the Cerebrospinal Fluid
(Pergamon-Elsevier Science Ltd., 2013-12-03)
Ghrelin is a stomach-derived peptide hormone that acts in the brain to regulate many important physiological functions. Ghrelin receptor, named the growth hormone secretagogue receptor (GHSR), is present in many brain areas ...
Des-Acyl Ghrelin Directly Targets the Arcuate Nucleus in a Ghrelin- Receptor Independent Manner and Impairs the Orexigenic Effect of Ghrelin
(Wiley Blackwell Publishing, Inc, 2016-02)
Ghrelin is a stomach-derived octanoylated peptide hormone that plays a variety of well-established biological roles acting via its specific receptor known as growth hormone secretagogue receptor (GHSR). In plasma, a ...
Ghrelin gene-related peptides modulate rat white adiposity
(Elsevier Inc, 2007)
It is known that ghrelin and des‐N‐octanoyl (desacyl) ghrelin modulate food intake and adipogenesis in vivo. However, desacyl ghrelin represents the majority of ghrelin forms found in the circulation. The present study ...
Divergent Neuronal Circuitries Underlying Acute Orexigenic Effects of Peripheral or Central Ghrelin: Critical Role of Brain Accessibility
(Wiley Blackwell Publishing, Inc, 2014-06)
Ghrelin is an octanoylated peptide hormone that potently and rapidly increases food intake. The orexigenic action of ghrelin involves the hypothalamic arcuate nucleus (ARC), which is accessible to plasma ghrelin and expresses ...
Evidence Supporting a Role for the Blood-Cerebrospinal Fluid Barrier Transporting Circulating Ghrelin into the Brain
(Springer, 2019-06)
The stomach-derived hormone ghrelin mainly acts in the brain. Studies in mice have shown that the accessibility of ghrelin into the brain is limited and that it mainly takes place in some circumventricular organs, such as ...
Plasma levels of ghrelin, des-acyl ghrelin and LEAP2 in children with obesity: Correlation with age and insulin resistance
(BioScientifica, 2019-11)
Objective: The octanoylated peptide hormone ghrelin regulates appetite and glycaemic control. Des-acyl ghrelin abolishes some effects of ghrelin, but does not bind to ghrelin receptor. LEAP2 is a novel ligand for ghrelin ...