Artículo de revista
A putative role for hypothalamic glucocorticoid receptors in hypertension induced by prenatal undernutrition in the rat
Fecha
2010Registro en:
Neuroscience Letters, Volumen 483, Issue 1, 2018, Pages 41-46
03043940
10.1016/j.neulet.2010.07.057
Autor
Pérez, Hernán
Soto Moyano, Rubén
Ruiz, Samuel
Hernández, Alejandro
Sierralta, Walter
Olivares, Ricardo
Núñez, Héctor
Flores, Osvaldo
Morgan, Carlos
López Valladares, Luis
Gatica, Arnaldo
Flores, Francisco J.
Institución
Resumen
Prenatal undernutrition induces hypertension later in life, possibly by disturbing the hypothalamo-pituitary-adrenal axis through programming decreased expression of hypothalamic glucocorticoid receptors. We examined the systolic blood pressure, heart rate and plasma corticosterone response to intra-paraventricular dexamethasone, mifepristone and corticosterone in eutrophic and prenatally undernourished young rats. Undernutrition was induced during fetal life by restricting the diet of pregnant mothers to 10. g daily (40% of diet consumed by well-nourished controls). At day 40 of postnatal life (i) intra-paraventricular administration of dexamethasone significantly reduced at least for 24. h both the systolic pressure (-11.6%), the heart rate (-20.8%) and the plasma corticosterone (-40.0%) in normal animals, while producing lower effects (-5.5, -8.7, and -22.3%, respectively) on undernourished rats; (ii) intra-paraventricular administration of the antiglucocorticoid receptor ligand mif