Synthesis of 4-arylpiperazine derivatives of moclobemide: Potential antidepressants with a dual mode of action

Abstract

We report here the synthesis of substituted 4-chloro-N-[3-oxo-3-(4-aryl-1-piperazinyl)-propyl] benzamides (5-9), as potential new antidepressants, incorporating in a single molecule structural moieties related to a dual pharmacological profile: MAO-A inhibitor and 5-HT1A receptor affinity.