Artículos de revistas
Solvent-free microwave synthesis of 3-(4-benzo[b]thiophene-2-carbonyl)-1-piperazinyl-1-benzo[b]thiophen-2-yl-1-propanones. New hetero bis-ligands with potential 5-HT1A serotonergic activity
Fecha
2008-08-01Registro en:
HETEROCYCLES 75(8): 1913-1929
0385-5414
Autor
Pessoa Mahana, Hernán
Kosche Cárcamo, Johann Albert
Ron Higuera, Nadia Betsabé
Recabarren Gajardo, Gonzalo Iván
Saitz Barría, Claudio
Pessoa, D.
Araya Maturana, Ramiro
Institución
Resumen
A novel series of 2-benzothiophenealkylpiperazine derivatives 11 (a-d) with potential affinity at 5-HT1A serotonin receptors have been synthesized via solvent-free, microwave-promoted Michael addition of benzo[b]thiophene piperazine derivatives 6(a-c) to substituted benzo[b]thiophen-2-yl propenones 10(b,c).