Mouse Liver Microsomes (mlm) Protect Erythrocytes Against Trifluoperazine (tfp) Induced And Mechanical Hemolysis Which Are Due To Tfp Microsomal Transformation And To The Action Of An Unidentified Water-soluble Microsomal Factor (uf).

Meirelles, N C; Malheiros, S V; Ruggiero, A C; Degterev, I A

Artículos de revistas

Registro en:

European Journal Of Drug Metabolism And Pharmacokinetics. v. 19, n. 4, p. 349-57

0378-7966

http://www.ncbi.nlm.nih.gov/pubmed/7737237

http://repositorio.unicamp.br/jspui/handle/REPOSIP/193757

7737237

http://repositorioslatinoamericanos.uchile.cl/handle/2250/1293990

Autor

Meirelles, N C

Malheiros, S V

Ruggiero, A C

Degterev, I A

Institución

Universidade Estadual de Campinas (Brasil)

Resumen

Trifluoperazine (TFP), a phenothiazine derivative, produces either hemolysis or protection of erythrocytes under isosmotic conditions in a dose-dependent manner. The hemolytic effect of TFP is abolished in the presence of mouse liver microsomes (MLM) which is due, in part, to drug incorporation, transformation and a MLM enzyme driven metabolism. An unidentified water-soluble factor (or factors) derived from MLM has been found to protect erythrocytes against both mechanical and TFP-induced isosmotic hemolysis.

349-57