Mouse Liver Microsomes (mlm) Protect Erythrocytes Against Trifluoperazine (tfp) Induced And Mechanical Hemolysis Which Are Due To Tfp Microsomal Transformation And To The Action Of An Unidentified Water-soluble Microsomal Factor (uf).

dc.creatorMeirelles, N C
dc.creatorMalheiros, S V
dc.creatorRuggiero, A C
dc.creatorDegterev, I A
dc.date
dc.date2015-11-27T12:18:27Z
dc.date2015-11-27T12:18:27Z
dc.date.accessioned2018-03-29T00:51:10Z
dc.date.available2018-03-29T00:51:10Z
dc.identifierEuropean Journal Of Drug Metabolism And Pharmacokinetics. v. 19, n. 4, p. 349-57
dc.identifier0378-7966
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/7737237
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/193757
dc.identifier7737237
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1293990
dc.descriptionTrifluoperazine (TFP), a phenothiazine derivative, produces either hemolysis or protection of erythrocytes under isosmotic conditions in a dose-dependent manner. The hemolytic effect of TFP is abolished in the presence of mouse liver microsomes (MLM) which is due, in part, to drug incorporation, transformation and a MLM enzyme driven metabolism. An unidentified water-soluble factor (or factors) derived from MLM has been found to protect erythrocytes against both mechanical and TFP-induced isosmotic hemolysis.
dc.description19
dc.description349-57
dc.languageeng
dc.relationEuropean Journal Of Drug Metabolism And Pharmacokinetics
dc.relationEur J Drug Metab Pharmacokinet
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectBiotransformation
dc.subjectCells, Cultured
dc.subjectErythrocytes
dc.subjectHemolysis
dc.subjectKinetics
dc.subjectMale
dc.subjectMice
dc.subjectMicrosomes, Liver
dc.subjectNadp
dc.subjectOsmolar Concentration
dc.subjectSolubility
dc.subjectTrifluoperazine
dc.subjectWater
dc.titleMouse Liver Microsomes (mlm) Protect Erythrocytes Against Trifluoperazine (tfp) Induced And Mechanical Hemolysis Which Are Due To Tfp Microsomal Transformation And To The Action Of An Unidentified Water-soluble Microsomal Factor (uf).
dc.typeArtículos de revistas


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