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Mostrando ítems 11-20 de 1866
Pulmonary Neutrophilic Inflammation and Noncommunicable Diseases: Pathophysiology, Redox Mechanisms, Biomarkers, and Therapeutics
(Mary Ann Liebert, 2020-07)
Significance: Pulmonary neurophilic inflammation (PNI) is the homing and activation of neutrophil with damage to the microvasculature. This process is involved in pulmonary damage in patients exposed to airborne pollutants ...
Chronic Chagas disease: Can prophylaxis and therapeutic vaccines crack this "hard nut"?
(Future Medicine, 2016-02)
Although, none of the therapeutic vaccines assessed so far have reached sterilizing immunity, the results obtained in terms of disease control indicate that immune intervention might be used for therapeutic purposes.
A time-series analysis of therapeutic alliance, interventions, and client’s clinical status in an evidence-based single-case study: Evidence for establishing change mechanisms in psychotherapy
(Taylor & Francis, 2016-05)
Objective: The goal of this study was to analyze the time-series of alliance, interventions, and clients post-sessions clinical status, to establish if alliance and adherence to cognitive-behavioral interventions preceded ...
Mucosal targeting of therapeutic molecules using genetically modified lactic acid bacteria: an update
(Oxford University Press, 2013-07)
Lactic acid bacteria (LAB) represent a heterogeneous group of microorganisms naturally present in many foods and those have proved to be effective mucosal delivery vectors. Moreover, some specific strains of LAB exert ...
Drug repositioning: current approaches and their implications in the precision medicine era
(Taylor & Francis, 2018-01)
Introduction: Drug repositioning implies finding new medical uses for existing drugs. It represents a cost-efficient approach, since the new indications are built on the basis of available information on pharmacokinetics, ...
Signal Transduction Pathways as Therapeutic Target for Chagas Disease
(Bentham Science Publishers, 2019-06)
Trypanosomatids are a group of flagellated unicellular eukaryotes, which cause serious human diseases including Chagas disease (Trypanosoma cruzi), sleeping sickness (Trypanosoma brucei spp.) and Leishmaniasis (Leishmania ...
Role of Hedgehog Signaling in Breast Cancer: Pathogenesis and Therapeutics
(MDPI, 2019-04)
Breast cancer (BC) is the leading cause of cancer-related mortality in women, only followed by lung cancer. Given the importance of BC in public health, it is essential to identify biomarkers to predict prognosis, predetermine ...
Inoculation site from a cutaneous melanoma patient treated with an allogeneic therapeutic vaccine: A case report
(Frontiers Media S.A., 2015-04)
We have developed a therapeutic vaccine consisting of a mixture of lethally-irradiated allogeneic cutaneous melanoma cell lines with BCG and GM-CSF as adjuvants. The CSF-470 vaccine is currently being assayed in a Phase ...
Neuregulin signaling is a mechanism of therapeutic resistance in head and neck squamous cell carcinoma
(American Association for Cancer Research, 2019-08)
EGFR signaling confers resistance to radiotherapy and is a validated target in head and neck squamous cell carcinoma (HNSCC). The inhibition of EGFR in combination with radiotherapy improves local control and overall ...
Medical cannabis in Argentina
(American Institute of the History of Pharmacy, 2019-12)
The aim of this paper is to examine the rise of therapeutic cannabis use in Argentina. The starting point is the recently implemented cannabis law 27350; it created a new legal framework to carry out scientific research ...