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Kinase inhibitors can produce off-target effects and activate linked pathways by retroactivity
(BioMed Central, 2011-10)
Background: It has been shown in experimental and theoretical work that covalently modified signaling cascades naturally exhibit bidirectional signal propagation via a phenomenon known as retroactivity. An important ...
Host receptor-targeted therapeutic approach to counter pathogenic New World mammarenavirus infections
(Nature Research, 2022)
Five New World mammarenaviruses (NWMs) cause life-threatening hemorrhagic fever (HF). Cellular entry by these viruses is mediated by human transferrin receptor 1 (hTfR1). Here, we demonstrate that an antibody (ch128.1/IgG1) ...
Regulation of the Norepinephrine Transporter by Endothelins: A potential therapeutic target
(Elsevier Academic Press Inc, 2015-03)
Neuronal norepinephrine (NE) uptake is a crucial step in noradrenergic neurotransmission that regulates NE concentration in the synaptic cleft. It is a key mechanism mediated by the NE transporter (NET) which takes the ...
Potential therapeutic targets for growth arrest of colorectal cancer cells exposed to PTHrP
(Elsevier Ireland, 2018-12-15)
Although PTHrP is implicated in several cancers, its role in chemoresistance is not fully elucidated. We found that in CRC cells, PTHrP exerts proliferative and protective effects and induces cell migration. The aim of ...
Prolactin and its receptor as therapeutic targets in glioblastoma multiforme
(Nature Publishing Group, 2019-12)
Although prolactin (PRL) and its receptor (PRLR) have been detected in glioblastoma multiforme (GBM), their role in its pathogenesis remains unclear. Our aim was to explore their contribution in GBM pathogenesis. We detected ...
P2X7 Receptor: A Potential Therapeutic Target for Depression?
(Elsevier, 2018-09)
Depression is a prime contributor to global disease burden with 300 million affected patients worldwide. The persistent lack of progress with regards to pharmacotherapy stands in stark contrast to the pandemic magnitude ...
Mechanistic insights into the pathogenesis of microtubule‐targeting agent‐induced peripheral neuropathy from pharmacogenetic and functional studies
(Wiley Blackwell Publishing, Inc, 2022-01)
Chemotherapy-induced peripheral neuropathy (CIPN) is a common dose-limiting toxicity that affects 30%-40% of patients undergoing cancer treatment. Although multiple mechanisms of chemotherapy-induced neurotoxicity have ...
Emerging Therapeutic Targets Against Toxoplasma gondii: Update on DNA Repair Response Inhibitors and Genotoxic Drugs
(Frontiers Media S.A., 2020-06)
Toxoplasma gondii is the causative agent of toxoplasmosis in animals and humans. This infection is transmitted to humans through oocysts released in the feces of the felines into the environment or by ingestion of undercooked ...
Relevance of small GTPase Rac1 pathway in drug and radio-resistance mechanisms: Opportunities in cancer therapeutics
(Elsevier Science Inc, 2018-04)
Rac1 GTPase signaling pathway has a critical role in the regulation of a plethora of cellular functions governing cancer cell behavior. Recently, it has been shown a critical role of Rac1 in the emergence of resistance ...
Pharmacological approaches towards rationalizing the use of endoparasitic drugs in small animals
(Wiley Blackwell Publishing, Inc, 2006-12)
Parasitic diseases are an important health concern to small animal veterinarians worldwide, and their zoonotic potential is also of relevance to human medicine. The treatment and control of such conditions relies heavily ...