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Chagas disease treatment: From new therapeutic targets to drug discovery and repositioning
(Bentham Science Publishers, 2019-12)
Chagas disease, caused by the protozoan Trypanosoma cruzi, currently affects millions of people worldwide although it is only endemic in America. Chagas is considered a neglected tropical disease because it afflicts the ...
Inflammation and insulin resistance as risk factors and potential therapeutic targets for Alzheimer’s disease
(Frontiers Media S.A., 2021-04)
Overnutrition and modern diets containing high proportions of saturated fat are among the major factors contributing to a low-grade state of inflammation, hyperglycemia and dyslipidemia. In the last decades, the global ...
Major kinds of drug targets in chagas disease or american trypanosomiasis
(Bentham Science Publishers, 2019-08-21)
American Trypanosomiasis, a parasitic infection commonly named Chagas disease, affects millions of people all over Latin American countries. Presently, the World Health Organization (WHO) predicts that the number of ...
Nuclear ErbB-2: A Novel Therapeutic Target in ErbB-2-Positive Breast Cancer?
(Springer, 2019-01)
Membrane overexpression of ErbB-2 (MErbB-2), a member of the ErbB family of receptor tyrosine kinases, occurs in 15– 20% of breast cancers (BC) and constitutes a therapeutic target in this BC subtype (ErbB-2-positive). ...
Innovative Therapeutic and Delivery Approaches Using Nanotechnology to Correct Splicing Defects Underlying Disease
(Frontiers Media, 2020-07)
Alternative splicing of pre-mRNA contributes strongly to the diversity of cell- and tissue-specific protein expression patterns. Global transcriptome analyses have suggested that >90% of human multiexon genes are alternatively ...
Highlighting the interplay of microRNAs from Leishmania parasites and infected-host cells
(Cambridge University Press, 2021-07)
Leishmania parasites, the causative agents of leishmaniasis, are protozoan parasites with the ability to modify the signaling pathway and cell responses of their infected host cells. These parasite strategies alter the ...
Dually responsive nanogels as smart carriers for improving the therapeutic index of doxorubicin for breast cancer
(Pergamon-Elsevier Science Ltd, 2019-07)
Nanocarriers can significantly improve the therapeutic index of drug in cancer therapy. At present, parenteral administration of free doxorubicin (Dox) to treat breast tumor produces severe side effects including cardiotoxicity. ...
Breast cancer as photodynamic therapy target: Enhanced therapeutic efficiency by overview of tumor complexity
(Baishideng Publishing Group, 2014-12)
Photodynamic therapy is a minimally invasive and clinically approved procedure for eliminating selected malignant cells with specific light activation of a photosensitizer agent. Whereas interstitial and intra-operative ...
Therapeutic improvement of a stroma-targeted CRAd by incorporating motives responsive to melanoma microenvironment
(Williams & Wilkins, 2013-11)
We have previously designed a conditionally replicative oncolytic adenovirus (CRAd) named Ad-F512 that can target both the stromal and the malignant melanoma cell compartments. The replication capacity of this CRAd is ...
Neuregulin signaling is a mechanism of therapeutic resistance in head and neck squamous cell carcinoma
(American Association for Cancer Research, 2019-08)
EGFR signaling confers resistance to radiotherapy and is a validated target in head and neck squamous cell carcinoma (HNSCC). The inhibition of EGFR in combination with radiotherapy improves local control and overall ...