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The role of the prolactin receptor pathway in the pathogenesis of glioblastoma: what do we know so far?
(Informa Healthcare, 2020-09-29)
Introduction: Prolactin (PRL) and its receptor (PRLR) have been associated with the development of hormone-dependent tumors and have been detected in glioblastoma (GBM) biopsies. GBM is the most common and aggressive primary ...
Cortical and meningeal pathology in progressive multiple sclerosis: A new therapeutic target?
(Freund & Pettman Publishers, 2019-04)
Multiple sclerosis (MS) is an inflammatory and neurodegenerative disease that involves an intricate interaction between the central nervous system and the immune system. Nevertheless, its etiology is still unknown. MS ...
Cytokines as therapeutic targets in primary Sjögren syndrome
(Pergamon-Elsevier Science Ltd, 2018-04-19)
Primary Sjögren syndrome (SjS) is a systemic autoimmune disease that may affect 1 in 1000 people (overwhelmingly women) and that can be a serious disease with excess mortality due to severe organ-specific involvements and ...
Mucosal targeting of therapeutic molecules using genetically modified lactic acid bacteria: an update
(Oxford University Press, 2013-07)
Lactic acid bacteria (LAB) represent a heterogeneous group of microorganisms naturally present in many foods and those have proved to be effective mucosal delivery vectors. Moreover, some specific strains of LAB exert ...
Bone diseases: Current approach and future perspectives in drug delivery systems for bone targeted therapeutics
(Multidisciplinary Digital Publishing Institute AG, 2020-05-01)
Bone diseases include a wide group of skeletal-related disorders that cause mobility limitations and mortality. In some cases, e.g., in osteosarcoma (OS) and metastatic bone cancer, current treatments are not fully effective, ...
Artificial Itelligence Teaches Drugs to Target Proteins by Tackling the Induced Folding Problem
(American Chemical Society, 2020-06-17)
We explore the possibility of a deep learning (DL) platform that steers drug design to target proteins by inducing binding-competent conformations. We deal with the fact that target proteins are usually not fixed targets ...
Methods to Investigate Signal Transduction Pathways in Trypanosoma cruzi: Cyclic Nucleotide Phosphodiesterases Assay Protocols
(Springer, 2020-03)
Intracellular levels of cyclic nucleotide second messengers are regulated predominantly by a large superfamily of phosphodiesterases (PDEs). Most of the different PDE variants play specific physiological functions; in fact, ...
Rho GTPasas como blancos moleculares en cáncer: estrategias y oportunidades terapéuticasRho GTPases as molecular targets in cancer. Strategies and therapeutic opportunities
(Medicina (Buenos Aires), 2017-12)
Las Rho GTPasas son una familia de proteínas que actúan como interruptores moleculares en diversas vías de señalización coordinando la regulación de distintos procesos celulares. La desregulación de dichas proteínas se ...
Role of Hedgehog Signaling in Breast Cancer: Pathogenesis and Therapeutics
(MDPI, 2019-04)
Breast cancer (BC) is the leading cause of cancer-related mortality in women, only followed by lung cancer. Given the importance of BC in public health, it is essential to identify biomarkers to predict prognosis, predetermine ...
The druggable pocketome of Corynebacterium diphtheriae: A new approach for in silico putative druggable targets
(Frontiers Research Foundation, 2018-02)
Diphtheria is an acute and highly infectious disease, previously regarded as endemic in nature but vaccine-preventable, is caused by Corynebacterium diphtheriae (Cd). In this work, we used an in silico approach along the ...