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Neutralization of coral snake Micrurus nigrocinctus venom by a monovalent antivenom
(1991)
The neutralizing ability of a monovalent anti-Micrurus nigrocinctus (coral snake) antivenom produced in Costa Rica was tested against the lethal, myotoxic and phospholipase A2 activities of homologous venom. In addition, ...
Neutralization of four Peruvian Bothrops sp. snake venoms by polyvalent antivenoms produced in Perú and Costa Rica: preclinical assessment
(2005-06)
Envenomations after bites inflicted by snakes of the genus Bothrops constitute a public health hazard in Perú, and the intravenous administration of equine-derived antivenoms represents the only scientifically validated ...
An MTT-based method for the in vivo quantification of myotoxic activity of snake venoms and its neutralization by antibodies
(1993-05)
The reduction of the tetrazolium compound MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl-tetrazolium bromide) was used as the basis for the development of a simple method for the quantitative estimation of metabolically ...
Membrane independent activation of fibroblast proMMP-2 by snake venom: novel roles for venom proteinases
(2004-12-01)
ProMMP-2 activation by Bothrops asper venom was investigated in mouse gastrocnemius muscle, mammalian cell culture and a cell-free system. Zymography revealed an increment of latent and activated forms of MMP-2 in muscle ...
Hemorrhage induced by snake venom metalloproteinases: biochemical and biophysical mechanisms involved in microvessel damage
(2005-06-15)
Zinc-dependent metalloproteinases are responsible for the hemorrhagic activity characteristic of viperid snake venoms. Snake venom metalloproteinases (SVMPs) are classified in various groups (P-I–IV), according to their ...
Bothrops asper: Beauty and peril in the Neotropics
(2009-12-01)
Snakes have inspired fascination and fear to humans since ancient times, as reflected by the common presence of these reptiles in the mythology of many civilizations. Such sense of awe has been associated to the impact ...
Comparison of venom composition and biological activities of the subspecies Crotalus lepidus lepidus, Crotalus lepidus klauberi and Crotalus lepidus morulus from Mexico
(2013-08-01)
The rock rattlesnakes Crotalus lepidus comprise a group (lepidus, klauberi, morulus and
maculosus) of poorly known mountain cold-tolerant snakes in Mexico. In particular, Crotalus
lepidus morulus is a snake endemic of ...
Neutralization of the cytolytic and myotoxic activities of phospholipases A2 from Bothrops asper snake venom by glycosaminoglycans of the heparin/heparan sulfate family
(1994)
Basic phospholipases A2 from the venom of Bothrops asper exhibit skeletal muscle damaging activity in vivo, and cytolytic activity to a variety of cell types in culture. Glycosaminoglycans of the heparin/heparan sulfate ...
Comparison of the adjuvant activity of aluminum hydroxide and calcium phosphate on the antibody response towards Bothrops asper snake venom
(2014)
The adjuvanticity of aluminum hydroxide and calcium phosphate on the antibody response in
mice towards the venom of the snake Bothrops asper was studied. It was found that, in vitro,
most of the venom proteins are similarly ...
Isolation and characterization of a metalloproteinase with weak hemorrhagic activity from the venom of the snake Bothrops asper (terciopelo)
(1995-01)
A metalloproteinase, named BaP1, was purified to homogeneity from the venom of Bothrops asper (Pacific region) of Costa Rica by ion-exchange chromatography on CM-Sephadex and gel filtration on Sephacryl S-200. The enzyme ...