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Synthesis, spectroscopic properties and photodynamic activity of two cationic BODIPY derivatives with application in the photoinactivation of microorganisms
(Elsevier Masson, 2016-10)
Two cationic BODIPYs 3 and 4 were synthesized by acid-catalyzed condensation of the corresponding pyrrole and benzaldehyde, followed by complexation with boron and methylation. Compound 3 contains methyl at the 1,3,5 and ...
Mechanistic insight into the photodynamic effect mediated by neutral red and a new azine compound in Staphylococcus aureus cells
(Wiley VCH Verlag, 2019-10)
The photodynamic activity of Neutral Red and the new monobrominated Neutral Red was studied in suspensions of Staphylococcus aureus. The effect of mannitol and sodium azide in the presence of 25 μm photosensitizer on lethal ...
Thionine in the design of new photosensitizers: Bromination and vehiculization in polymeric nanoparticles
(Elsevier Science, 2020-07-15)
To face the challenges of optimizing the properties of the photosensitizers currently used in the photodynamic inactivation of various microorganisms, we propose the bromination of thionine and the use of polymeric ...
Photodynamic inactivation of planktonic and biofilm growing bacteria mediated by a meso-substituted porphyrin bearing four basic amino groups
(Elsevier Science Sa, 2016-08)
Biofilm-associated diseases account for 80% of all infections in humans. Due to the emergence of antibiotic resistances, alternative therapies such as Photodynamic Inactivation (PDI) of microorganisms have emerged. Porphyrins ...
Effectiveness of ZnPc and of an amine derivative to inactivate Glioblastoma cells by Photodynamic Therapy: An in vitro comparative study
(Nature Publishing Group, 2019-12)
Glioblastoma multiforme is considered to be one of the most aggressive types of tumors of the central nervous system, with a poor prognosis and short survival periods of ~ one year. The current protocol for glioblastoma ...
BODIPYs in antitumoral and antimicrobial photodynamic therapy: An integrating review
(Elsevier Science, 2019-09)
Nowadays, both cancer and infections caused by antibiotic resistant microorganisms are problems that affect the entire planet. Phototherapy (namely photodynamic therapy (PDT) and photodynamic inactivation (PDI) of ...
Antimicrobial photodynamic polymeric films bearing biscarbazol triphenylamine end-capped dendrimeric Zn(II) porphyrin
(American Chemical Society, 2019-07-16)
A novel biscarbazol triphenylamine end-capped dendrimeric zinc(II) porphyrin (DP 5) was synthesized by click chemistry. This compound is a cruciform dendrimer that bears a nucleus of zinc(II) tetrapyrrolic macrocycle ...
Proton-Dependent switching of a novel amino chlorin derivative as a fluorescent probe and photosensitizer for acidic media
(Wiley VCH Verlag, 2018-04)
A novel chlorin derivative (TPCF20-NMe2) was synthesized as a syn adduct of a pyrrolidinefused chlorin carrying an C-linked N,N-dimethylaminophenyl residue. The absorption spectrum of TPCF20-NMe2 was basically identical ...
Functionalized Magnetic Nanoparticles with BODIPYs for Bioimaging and Antimicrobial Therapy Applications
(American Chemical Society, 2020-01)
The antimicrobial capability and recyclability of two conjugates that combines the versatility of iron oxide magnetic nanoparticles (MNPs) with the high photosensitizing proficiency of boron-dipyrromethene (BODIPY) dyes ...
A novel tricationic fullerene C60 as broad-spectrum antimicrobial photosensitizer: Mechanisms of action and potentiation with potassium iodide
(Royal Society of Chemistry, 2021-03)
A novel amphiphilic photosensitizing agent based on a tricationic fullerene C60 (DMC603+) was efficiently synthesized from its non-charged analogue MMC60. These fullerenes presented strong UV absorptions, with a broad range ...