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Mostrando ítems 11-20 de 91
Pharmacokinetic/pharmacodynamic relationships of antimicrobial drugs used in veterinary medicine
(Wiley Blackwell Publishing, Inc, 2004-12)
The rise in incidence of antimicrobial resistance, consumer demands and improved understanding of antimicrobial action has encouraged international agencies to review the use of antimicrobial drugs. More detailed understanding ...
Effects of tetrahydrouridine on pharmacokinetics and pharmacodynamics of oral decitabine
(American Society of Hematology, 2012-02)
The deoxycytidine analog decitabine (DAC) can deplete DNA methyl-transferase 1 (DNMT1) and thereby modify cellular epigenetics, gene expression, and differentiation. However, a barrier to efficacious and accessible ...
Solid Lipid Nanoparticles for Drug Delivery: Pharmacological and Biopharmaceutical Aspects
(Frontiers Media S.A., 2020-10-30)
In the golden age of pharmaceutical nanocarriers, we are witnessing a maturation stage of the original concepts and ideas. There is no doubt that nanoformulations are extremely valuable tools for drug delivery applications; ...
Efficacy of florfenicol for the treatment of infections by Pasteurella multocida and Mannheimia haemolitica in alpacas (Vicugna pacos)Eficacia de florfenicol para el tratamiento de infecciones por Pasteurela multocida y Mannheimia haemolitica en alpacas (Vicugna pacos)
(Universidad Nacional Mayor de San Marcos, Facultad de Medicina Veterinaria, 2019)
The role of hyaluronan as a drug carrier to enhance the bioavailability of extended release ophthalmic formulations. Hyaluronan-timolol ionic complexes as a model case
(Elsevier Science, 2017-07-15)
The aim of this work was to obtain information concerning the properties of ophthalmic formulations based on hyaluronic-drug ionic complexes, to identify the factors that determine the onset, intensity and duration of the ...
Obtención de un modelo múrido de diabetes inducida por estreptozotocina útil en la evaluación farmacodinámica de la insulina regularObtaining a murine model of streptozotocin-induced diabetes useful in the pharmacodynamic evaluation of regular insulin
(Universidad de Antioquia, Facultad de Ciencias Farmacéuticas y AlimentariasGRIPE: Grupo Investigador de Problemas en Enfermedades InfecciosasMedellín, Colombia, 2021)
Development of a Minimal Physiologically-Based Pharmacokinetic Model to Simulate Lung Exposure in Humans Following Oral Administration of Ivermectin for COVID-19 Drug Repurposing
(Elsevier, 2020-12-01)
SARS-CoV-2 utilizes the IMPα/β1 heterodimer to enter host cell nuclei after gaining cellular access through the ACE2 receptor. Ivermectin has shown antiviral activity by inhibiting the formation of the importin-α (IMPα) ...
Pharmacokinetic-pharmacodynamic (PK-PD) modeling of cardiovascular effects of metoprolol in spontaneously hypertensive rats: a microdialysis study
(Springer, 2006-05)
The present work addressed possible alterations inthe pharmacokinetics and the in vivo pharmacodynamic ofmetoprolol (MET) in spontaneously hypertensive (SH) ratsand Wistar Kyoto (WKY) animals by means of the microdialysi ...
Vitamin D receptor exhibits different pharmacodynamic features in tumoral and normal microenvironments: A molecular modeling study
(Pergamon-Elsevier Science Ltd, 2020-03-03)
The vitamin D receptor (VDR) constitutes a promising therapeutic target for the treatment of cancer. Unfortunately, its natural agonist calcitriol does not have clinical utility due to its potential to induce hypercalcemic ...