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Increased nitration and diminished activity of copper/zinc superoxide dismutase in placentas from diabetic rats
(Taylor & Francis, 2010-12)
Nitration-induced protein damage in the placenta leads to impaired blood flow and deficient feto–placental exchange in diabetic pregnancies. This work studied the effect of nitric oxide and peroxynitrite on Cu/Zn SOD ...
Mechanism of the Reaction of Peroxynitrite with Mn-Superoxide Dismutase: Nitration of Critical Tyrosine-34
(Elsevier Science Inc, 2014-11)
Manganese superoxide dismutase (MnSOD) is an antioxidantenzyme that acts as a superoxide detoxifier. Superoxide can reactwith nitric oxide to lead peroxynitrite and this reaction, that takesplace at near diffusion limited ...
What Are the Key Arguments Against Uric Acid as a True Risk Factor for Hypertension?
(Lippincott Williams & WilkinsPhiladelphiaEUA, 2013)
Laminar lesions in horses with systemic oxidative stress, committed by experimentally induced or naturally occurring gastrointestinal disorders
(2016-01-01)
Laminitis in horses can be associated with lesions in multiple organs secondary to sepsis. Twenty-one horses suffering from gastrointestinal disorders were used in the experiment; 7 horses with experimentally induced ...
The role of superoxide anion in the inhibitory effect of SIN-1 in thrombin-activated human platelet adhesion
(Elsevier Science BvAmsterdamHolanda, 2010)
Direct evidence of singlet molecular oxygen generation from peroxynitrate, a decomposition product of peroxynitrite
(ROYAL SOC CHEMISTRY, 2009)
The decomposition of peroxynitrite to nitrite and dioxygen at neutral pH follows complex kinetics, compared to its isomerization to nitrate at low pH. Decomposition may involve radicals or proceed by way of the classical ...
Platelet-derived exosomes induce endothelial cell apoptosis through peroxynitrite generation: experimental evidence for a novel mechanism of septic vascular dysfunction
(2007)
Abstract
Introduction
Several studies link hematological dysfunction to severity of sepsis. Previously we showed that ...
Platelet-derived exosomes induce endothelial cell apoptosis through peroxynitrite generation: experimental evidence for a novel mechanism of septic vascular dysfunction
(2007-09-25)
Abstract
Introduction
Several studies link hematological dysfunction to severity of sepsis. Previously we showed that platelet-derived microparticles from septic patients ...